The Open Access journal Genomics Proteomics & Bioinformatics (GPB) is now inviting submissions for a special issue (to be published around December 2012) on the topic of “Gene Regulatory Network”. The Gene Regulatory Network (GRN) is a collection of DNA sequences which interact with each other and other cellular components, thereby governing the rates at which genes in the network are transcribed to change the genomic activity. GRNs are evolutionally -conserved and play critical roles in various biological processes and attract more and more research interest. We are pleased to announce a special issue on “Gene Regulatory Network” to act as both a focus and a stimulus for research on these key regulatory genes. Dr. Roger Patient from Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital and Dr. Matt Loose from The University of Nottingham will be the Guest Editors of this issue. The aim is to provide a platform for publication of high-quality papers on recent advances and developments in this important area. The topics may include (but not be limited to) experimental approaches used in GRN research, GRNs in different biological processes and during evolution, modeling and designing of GRN, and the regulation of GRNs including by transcription factors, miRNA, epigenetics, and 3D structure of chromosomes. Original studies, reviews, methods, application notes, etc are all welcome.The portfolio will be open for incoming manuscripts till October 31, 2012. Manuscripts can be submitted online at http://ees.elsevier.com/gpb/. The Guide for Authors is also available on this website. Note to mention that the submission is for this special issue. For further information, please contact us: Dr. Patient (roger.patient@imm.ox.ac.uk); Dr. Loose (matt.loose@nottingham.ac.uk); The Editorial Office of GPB (editor@big.ac.cn; Tel: +86-10-82995372 ).