Qiang Shan, Xiaomin Lou, Ting Xiao, Ju Zhang, Huiying Sun; Yanning Gao, Shujun Cheng; Lin Wu; Ningzhi Xu, Siqi Liu

Cancer Letters Volume 328, Issue 1, 1 January 2013, Pages 160–167

Abstract

Cancer/testis antigens (CTAs) are highly immunogenic in many tumors, especially in non-small cell lung cancer (NSCLC). A low-density protein microarray, which consisted of 72 CTAs and six non-CTAs, was used to screen for lung cancer-related autoantibodies. The CTA panel of NY-ESO-1, XAGE-1, ADAM29 and MAGEC1, had sensitivity and specificity values of 33% and 96%, respectively. When examined in a test set, this panel of markers had sensitivity and specificity values of 36% and 89%, respectively. This array of markers preferentially detected NSCLC, but did not detect breast cancer, and non-cancer lung disease.