People

CI Weimin

Professor in Genomics

Beijing Institute of Genomics, Chinese Academy of Sciences

NO.1 Beichen West Road, Chaoyang District,

Beijing 100101, China

Tel：+86-10-84097318

Email：ciwm@big.ac.cn

Group Leader

Dr. CI is currently a professor of Beijing Institute of Genomics, Chinese Academy of Sciences (CAS). She got her PhD from Institute of Biophysics, CAS in 2004. And from 2004 to 2009, she got her Postdoc training in Albert Einstein College of Medicine and Cornell Medical College, respectively. Then, she joined Beijing Institute of Genomics at 2009. 

Introduction:

Dr. CI's current research focuses on DNA methylation reprogramming in tissue-specific cell differentiation and tumorigenesis. The ultimate goal of my laboratory is to define the DNA methylation changes that occur in cancers especially renal cell carcinomas, to discover the molecular causes of these changes, and to translate that newly gained knowledge into the clinic in the form of novel, epigenetic-based therapies. A wide spectrum of experimental approaches will be employed, including molecular and cellular biology, biochemistry, genomics and proteomics. 

Selected publications

1. Qin MA, Huan LU, Ziying XU, Yuanyuan ZHOU & Weimin CI*. Mouse olfactory bulb methylome andhydroxymethylome maps reveal noncanonical active turnover of DNA methylation, Epigenetics, 2017, 12(8):708-714

2. Ester VALLS, Camille LOBYR, Huimin GENG, Ling WANG, Mariano CARDENAS, Martín RIVAS, Leandro CERCHIETTI, Philmo OH, Shao Ning YANG, Erin OSWALD, Camille W. GRAHAM, Yanwen JIANG, Katerina HATZI, Xabi AGUIRRE, Eric PERKEY, Zhuoning LI, Wayne TAM, Kamala BHATT, Spyros Artavanis-Tsakonas, John P. LEONARD, Patrick A. Zweidler-McKay, Ivan MAILLARD, Olivier ELEMENTO, Weimin CI*, Iannis AIFABTIS* and Ari MELNICK*. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells, Cancer Discovery, 2017, 7(5):506-521.

3. Ke CHEN#, Jing ZHANG#, Zhongqiang GUO#, Qin MA, Zhengzheng XU, Yuanyuan ZHOU, Ziying XU, Zhongwu LI, Yiqiang LIU, Xiongjun YE, Xuesong LI, Bifeng YUAN, Yuwen KE, Chuan HE, Liqun ZHOU*, Jiang LIU*, and Weimin CI*. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer, Cell Research, 2016, 26(1):103-118.

4. Weimin CI# and Jiang LIU*.Programming and Inheritance of Parental DNA Methylomes in Vertebrates, Physiology, 2015, 30(1): 63– 68.

5. Lu Wang#, Jun Zhang#, Jialei Duan#, Xinxing Gao#, Wei Zhu, Xingyu Lu, Lu Yang, Jing Zhang, Guoqiang Li, Weimin Ci, Wei Li, Qi Zhou, Neel Aluru, Fuchou Tang, Chuan He, Xingxu Huang*, Jiang Liu *，Programming and inheritance of parental DNA methylomes in mammals, Cell, 2014, 157(4),979-999.

6. Guoqiang LI#, Weimin CI#, Subhradip KARMAKAR#, Ke CHEN, Ruby DHAR, Zhixiang FAN, Zhongqiang GUO, Jing ZHANG, Yuwen KE, Lu WANG, Min ZHUANG, Shengdi HU, Xuesong LI, Liqun ZHOU, Xianghong LI, Matthew F. CALABRESE, Edmond R. WATSON, Sandip M. PRASAD, Carrie RINKER-SCHAEFFER, Scott E. EGGENER, Thomas STRICKER, Yong TIAN, Brenda A. SCHULMAN, Jiang LIU*, Kevin P. WHITE*. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer, Cancer Cell, 2014, 25(4)：455-468.

7. Lan JIANG#, Jing ZHANG#, Jing-Jing WANG#, Lu WANG, Li ZHANG, Guoqiang LI, Xiaodan YANG, Xin MA, Xin SUN, Jun CAI, Jun ZHANG, Xingxu HUANG, Miao Yu, Xuegeng WANG, Feng LIU, Chung-I WU, Chuan HE, Bo ZHANG, Weimin CI*, Jiang LIU*. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos, Cell, 2013, 153(4):773-784.

8. Weimin CI#, Jose M POLO, Leandro CERCHIETTI, Rita SHAKNOVICH, Ling WANG, Shaoning YANG, Kenny YE, Pedro FARINHA, Douglas E. HORSMAN, Randy D. GASCOYNE, Olivier ELEMENTO, Ari MELNICK*. The BCL6 transcriptional program features repression of multiple oncogenes in primary B-cells and is deregulated in DLBCL. Blood, 2009, 113(22):5536-5348.

9. Jose M POLO#, Weimin CI#, Jonathan D LICHT, Ari MELNICK*, Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B-cells. Blood, 2008, 112(3):644-651.

10. Weimin CI#, Jose M POLO#, Ari MELNICK*. B-cell lymphoma 6 and the molecular pathogenesis of non-Hodgkin’s lymphoma. 2008. Curr Opin Hematol. 15(4):381-390.

11. Weimin CI#, Wenyu LI, Ke YA, Zhong-ming QIAN, Xun SHEN*. Intracellular Calcium Regulates the Cellular Iron Uptake in K562 Cells. 2003. Cell Calcium. 33:257-266.

Group Member

Staff

CHEN Ke (Assistant Professor); Email: chenke@big.ac.cn

ZHOU Yuanyuan (Research assistant); Email: zhouyy@big.ac.cn

SHI Yue (Assistant Professor); Email: shiyue@big.ac.cn 

Graduate Student: