Dr. LIU Xin is currently a professor at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). She also serves as an adjunct assistant professor in the Department of Pediatrics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Dr. LIU received a bachelor’s degree in clinical medicine from Shandong Medical University, China in 1993, and a Ph.D. in genetic epidemiology from Johns Hopkins University Bloomberg School of Public Health (JHBSPH), Baltimore, Maryland, USA, in 2002 (thesis advisor: Dr. Terri H Beaty). Dr. LIU pursued her postdoctoral training in the Department of Epidemiology at JHBSPH under the supervision of Dr. Margaret Daniele Fallin, and then in the Department of Epidemiology and Biostatistics at the University of California at San Francisco under the supervision of Dr. John S. Witte. Before joining the faculty at Beijing Institute of Genomics, Dr. LIU was an Assistant Professor in the Department of Pediatrics (2007-2015) and Preventive Medicine (2011-2015), at Northwestern University Feinberg School of Medicine.
Dr. LIU Xin has extensive experience in genetic epidemiological studies of complex diseases, including prostate cancer and childhood diseases. She has authored and co-authored ~60 publications in peer-reviewed scientific journals. Dr. LIU was the PI (R03 AI105294, R21AI087888) and co-investigator of several NIH-funded large-scale genetic epidemiological studies of food allergy, preterm birth and obesity.
Selected Publications
First Author Articles
1. Liu X, Nickel R, Beyer K, Wahn U, Ehrlich E, Freidhoff LR, Bj？rkstén B, Beaty TH, Huang SK and the MAS-Study Group. An IL13 coding region variant is associated with high total serum IgE level and atopic dermatitis in German Multicenter Atopy Study (MAS-90). The Journal of Allergy and Clinical Immunology 2000;106:167-170.
2. Liu X, Beaty TH, Deindl P, Huang SK, Lau S, Sommerfeld C, Fallin D, Kao WH, Wahn U, Nickel R. Association between total serum IgE levels and the six potentially functional variants within genes IL4, IL13 and IL4Rα in German Children: the German Multicenter Atopy Study (MAS). The Journal of Allergy and Clinical Immunology 2003:112:382-388.
3. Liu X, Beaty TH, Deindl P, Huang SK, Lau S, Sommerfeld C, Fallin D, Kao WH, Wahn U, Nickel R. Association between specific serum IgE response and 6 variants within genes IL4, IL13 and IL4Rα in German Children: the German Multicenter Atopy Study (MAS). The Journal of Allergy and Clinical Immunology 2004;113:489-95.
4. Liu X, Fallin MD, Kao WH. Genetic dissection methods: designs used for tests of gene-environment interaction. Current Opinion in Genetics & Development 2004;14:241-245.
5. Liu X, Jorgenson E, Witte JS. Hierarchical modeling in association studies of multiple phenotypes. BMC Genetics 2005;6(S1):S104. PMCID: PMC1866835
6. Liu X, Rybicki BA, Casey G, Witte JS. Relationship between body size and prostate cancer in a sibling-based case-control study. The Journal of Urology 2005;174:2169-2173.
7. Cicek MS, Liu X, Casey G, Witte JS. Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11α in prostate cancer risk and aggressiveness. Cancer Epidemology, Biomarkers & Prevention 2005;14:2173-2177. (Co-first author)
8. Liu X, Plummer SJ, Nock NL, Casey G, Witte JS. Nonsteroidal Anti-inflammatory Drugs and Decreased Risk of Advanced Prostate Cancer: Modification by Lymphotoxin Alpha. American Journal of Epidemiology 2006;164:984-989.
9.Liu X, Cicek MS, Plummer SJ, Jorgenson E, Casey G, Witte JS. Association of Testis-Derived Transcript (TES) gene variants and prostate cancer risk. The Journal of Urology 2007;177:894-8.
10. Zhang S, Liu X, Yu Y, Hong X, Christoffel KK, Wang B, Tsai HJ, Li Z, Liu X, Tang G, Xing H, Brickman WJ, Zimmerman D, Xu X, Wang X. Genetic and Environmental Contributions to Phenotypic Components of Metabolic Syndrome: A Population-based Twin Study. Obesity 2009;(17)8:1581-87. PMCID: PMC Journal-In Process (Co-first author)
11.Hong X, Tsai HJ, Liu X, Arguelles L, Kumar R, Wang GY, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Pongracic JA, Schleimer R, Holt PG, Bauchner H, Wang XB. Does Genetic Regulation of IgE Begin In-Utero? Evidence from TH1/TH2 Gene Polymorphisms and Cord Blood Total IgE. The Journal of Allergy and Clinical Immunology 2010;126(5):1059-1067. PMCID: PMC3020083 (Co-first author)
12.Liu X, Cheng I, Plummer SJ, Suarez B, Casey G, Catalona WJ, Witte JS. Fine mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. The Prostate 2011;71(7): 682-685. PMCID: PMC3027848.
13.Zhang S, Liu X, Kim JS, Ouyang F, Wang B, Li Z, Tang G, Liu X, Yang J, Xu X, Wang X. Association between short sleep duration and the risk of sensitization to food and aero allergens in Rural Chinese Adolescents. Clinical and Experimental Allergy 2011;41(4):547-55. PMCID: PMC3056931 (Co-first author)
14.Liu X, Zheng YN, Zhang W, Zhang X, LIoyd-Jones DM, Baccarelli AA, Ning HY, Fornage M, He K, Liu K, Hou LF. BLOOD METHYLOMICS IN RESPONSE TO ARSENIC EXPOSURE IN A LOW–EXPOSED US POPULATION. Journal Of Exposure Science And Environmental Epidemiology 2014;24(2):145-9
Corresponding Author (*) Articles
1. Zhang Y, Gao Y, Zhang H, Zhang J, He F, Hnízda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang Q, Yang JJ*, Zhu X*, Liu X*. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. Blood. 131(20):2256-2261,2018
2. Liu X*, Hong X, Tsai HJ, Mestan KK, Shi M, Kefi A, Hao K, Chen Q, Wang G, Caruso D, Geng H, Gao Y, He J, Kumar R, Wang H, Yu Y, Bartell T, Tan XD, Schleimer RP, Weeks DE, Pongracic JA, Wang X. Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine. 97(9):e0043,2018
3. Liu X *, Schumacher FR, Plummer SJ, Jorgenson E, Casey G, Witte JS *. Trans Fatty Acid Intake and Increased Risk of Advanced Prostate Cancer: Modification by RNASEL R462Q Variant. Carcinogenesis, 2007;28:1232-6.
4. Liu X *, Zhang SC, Tsai HJ, Hong XM, Wang BY, Fang YP, Liu X, Pongracic J, Wang X. Genetic and Environmental Contributions to Allergen Sensitization in a Chinese Twin Study. Clinical and Experimental Allergy 2009 Jul;39(7):991-8. PMCID: PMC2756049
5. Liu X *, Wang GY, Hong XM, Wang D, Tsai HJ, Zhang SC, Arguelles L, Kumar R, Wang HJ, Liu R, Zhou Y, Pearson C, Ortiz K, Schleimer R, Holt P, Pongracic J, Price HE, Langman C, Wang XB. Gene-Vitamin D interactions on food sensitization: a prospective birth cohort study. Allergy 2011;66(11):1442-8. PMCID: PMC3189275 [Available on 2012/11/1]
6. Liu X *, Wang GY, Hong XM, Tsai HJ, Liu R, Zhang SC, Wang HJ, Pearson C, Ortiz K, Wang D, Hirsch E, Zuckerman B, Wang XB. Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a U.S. urban black population. Human Genetics 2012;131(3):341-51.
7. Wang D *, Liu X *, Zhou Y, Xie H, Hong XM, Tsai HJ, Wang GY, Liu R, Wang XB. Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. Epigenetics 2012 Jun 1;7(6): 594-605.
8. Xing CH, Chen Q, Li GL, Zhang LY, Zheng M, Zou ZY, Hou LF, Wang QF, Liu X *, Guo XB *. Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers. Environmental and Molecular Mutagenesis. 2013;54(6): 397-405.
9. Liu X *, Arguelles L, Zhou Y, Wang GY, Chen Q, Tsai HJ, Hong XM, Liu R, Price HE, Pearson C, Apollon S, Cruz N, Schleimer R, Langman CB, Pongracic J, Wang XB. Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization. Pediatric Research. 2013; 74(3):321-6
10. Liu X *, Chen Q, Tsai HJ, Wang GY, Hong XM, Zhou Y, Zhang CL, Liu CY, Liu R, Wang HJ, Zhang SC, Yu YX, Mestan K, Pearson P, Otlans P, Zuckerman P, Wang XB. Maternal Pre-conception Body Mass Index and Offspring Cord Blood DNA Methylation: Exploration of Early Life Origins of Disease. Environmental and Molecular Mutagenesis 2014;55(3):223-30
Co-author Articles (Selected)
1. Chang YP, Liu X, Kim J, Ikeda MA, Layton M, Weder A, Cooper R, Kardia S, Rao DC, Hunt S, Luke A, Boerwinkle E, Chakravarti A. Multiple Essential Hypertension Susceptibility Genes On Chromosome 1q. American Journal of Human Genetics 2007; 80: 253-264. PMCID: PMC1785356
2. Cheng I, Liu X, Plummer SJ, Krumroy LM, Casey G, Witte JS. COX2 Genetic Variation, NSAIDs, and Advanced Prostate Cancer Risk. British Journal of Cancer 2007; 20;97(4):557-61. PMCID: PMC2360347
3. Hong X, Wang G, Liu X, Kumar R, Tsai H, Arguelles L, Hao K, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Caruso D, Pongracic J, Schleimer R, Holt P, Bauchner H, Wang X. Hong Gene Polymorphisms, Breastfeeding and Development of Food Sensitization in Early Childhood. Journal of Allergy & Clinical Immunology 2011 Aug;128(2):374-81.e2.
4. Liu R, Liu X, Arguelles L, Patwari, PP, Zee PC, Chervin RD, Ouyang F, Christoffel KK, Zhang SC, Wang GY, Xu X, Wang XB. A population-based twin study on sleep duration and body composition. Obesity 2012;20(1):192-9
5. Check J, Gotteiner N, Liu X, Porta N, Su E, Steinhorn R, Mestan K. Fetal Growth Restriction and Pulmonary Hypertension in Premature Infants with Bronchopulmonary Dysplasia. Journal of Perinatology 2013; 33(7): 553-7
6. Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z, Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G, Cheng T, Wang QF. Identification of Functional Cooperative Mutations of SETD2 in Human Acute Leukemia. Nature Genetics 2014;46(3): 287-93.
7. Liu R, Liu X, Zee PC, Hou LF, Zheng Z, Wei Y, Du J. Association between Sleep Quality and C-Reactive Protein: Results from National Health and Nutrition Examination Survey, 2005-2008. Plos One 2014;9(3):e92607
8. Mestan KK, Check J, Minturn L, Farrow KN, Liu X, Su E, Ernst LM. Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension. Placenta 2014; 35(8):570-4.
9. Hong XM, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun YF, Wang GY, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao PS, Chen Z, Walker S, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang XB. Genome-wide Association Study of Food Allergy Identifies Peanut Allergy-Specific Susceptibility Loci and Evidence of Epigenetic Mediation in U.S. Children of European Ancestry. Nature Communication 2015 Feb 24;6:6304. doi: 10.1038/ncomms7304.
10. Chuang SY, Yu YX, Sheu WH, Tsai YT, Liu X, Hsiung CA, Tsai HJ. Association of Short-Term Use of Nonsteroidal Anti-Inflammatory Drugs With Stroke in Patients With Hypertension. Stroke 2015 46(4):996-1003
11. Hong XM, Ladd-Acosta C, Hao K, Sherwood B, Ji HK, Keet CA, Kumar R, Caruso D, Liu X, Wang GY, Chen Z, Ji YL, Mao GY, Walker S, Bartell TR, Ji Z, Sun Y, Tsai HJ, Pongracic JA, Weeks DE, Wang XB. Epigenome-wide association study links site-specific DNA methylation changes with cow’s milk allergy. Journal of Allergy & Clinical Immunology (in press).
