Group leader
Dr. JIANG Lan, is a principal investigator at the Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). He received his bachelor's degree in Wuhan University. He then earned his Ph.D. degree from BIG. He finished his postdoctoral training at Harvard Medical School in 2018. After that, he joined BIG as a PI. He has got funding from the National Key Research and Development Program of China, the Natural Science Foundation of China, the Strategic Priority Research Program of the Chinese Academy of Sciences, the International Partnership Program of the Chinese Academy of Sciences, etc.
Introduction
Dr. JIANG Lan’s contribution to science includes 1) the development of single-cell genomics analysis methods, 2) the discovery of H3K27me3 as an imprinting mark in mammalian, 3) understanding the role of DNA methylation dynamics in gene regulation in early embryos and embryonic stem cells. He has published 12 Corresponding author or first-author papers in peer-reviewed journals including Nature, Cell, Genome Biology, etc. Dr. JIANG’s group will mainly focus on:
1. To develop novel single-cell resolution multi-omics techniques and computational approaches.
2. To study the roles of gene regulation in development and disease.
3. The application of AI in the interpretation of single-cell omics data.
Selected Publications
（# first author *Corresponding author）
1.Yun Li#; Zheng Huang#; Zhaojun Zhang#; Qifei Wang; Fengxian Li; Shufang Wang; Xin Ji; Shaokun Shu; Xiangdong Fang; Lan Jiang*; FIPRESCI: droplet microfluidics based combinatorial indexing for massive-scale 5′-end single-cell RNA sequencing, Genome Biology, 2023, 24(1):70
2.Shan Jiang#; Zheng Huang#; Yun Li#; Chengwei Yu#; Hao Yu; Yuwen Ke; Lan Jiang*; Jiang Liu*; Single-cell chromatin accessibility and transcriptome atlas of mouse embryos, Cell Reports, 2023, 42(3):112210
3.Azusa Inoue#, Lan Jiang#, Falong Lu#, Tsukasa Suzuki, Yi Zhang*, Maternal H3K27me3 controls DNA methylation-independent imprinting, Nature, 2017, 547(7664): 419-424
4.Lan Jiang, Huidong Chen, Luca Pinello, Guo-Cheng Yuan*, GiniClust: detecting rare cell types from single-cell gene expression data with Gini index, Genome Biology, 2016, 17: 144
5.Lan Jiang#, Jing Zhang#, Jing-Jing Wang#, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*; Jiang Liu*, Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos, Cell, 2013, 153(4): 773-784
Monograph
1.Lan Jiang, Computational methods for single-cell data analysis (Chapter 5: Rare Cell Type Detection), Humana Press, 2019
Group Members
Staff:
Dr. LI Guochao, Assistant Professor
Ms. LIANG Liji, Lab Manager
Graduate Students：
LI Yun, 2018
LIU Mengmeng, 2019
XU Chu, 2019
YU Chengwei, 2019
HUANG Zheng, 2019
AI Na, 2020
WANG Qifei, 2022
YUAN Yang, 2020
CHEN Shenzhi, 2020
XU Yangqing, 2021
CHEN Yanjie, 2022
MENG Xini, 2022
1. Charles A. King Trust Postdoctoral Research Fellowship（2017）
2. Harvard Medical School Epigenetics Travel Grant（2017）
3. Excellent Doctoral Dissertation, Chinese Academy of Sciences (2014)
4. The Ray Wu Prize for Excellence in Innovation, Independent Thinking, and Dedication, The Ray Wu Memorial Fund, Inc (2013)
5. The Special Prize of the President Scholarship for Postgraduate Students, Chinese Academy of Sciences (2013)
