- A Link Found Between Variable CTCF Occupancy and DNA Methylation(2012-12-14)
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CTCF is a ubiquitously expressed regulator of fundamental genomic processes including transcription, intra- and interchromosomal interactions, and chromatin structure. CTCF binding patterns are widely believed to be largely inv...
- Systematic Connecting Common Disease-associated Variation with Regu...(2012-12-13)
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Studies that compare the genomes of sick and healthy individuals have turned up a plethora of gene variants that are associated with certain diseases. A new study conducted by Professor John A. Stamatoyannopolous and his collea...
- Bioinformatics clouds for big data manipulation(2012-12-05)
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With the fast growing of high-throughput sequencing technologies, biological data is expending dramatically. Bioinformaticians are facing difficulties in storage and analysis of such vast amounts of data. As establishing a...
- Mammalian RNA Demethylase ALKBH5 Impacts RNA Metabolism and Mouse F...(2012-11-28)
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N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. A collaborative study, conducted in the laboratory of prof. YANG Yungui from Beijing Institute of Genomics (BIG)...
- A Pendulum Model to Explain Relationship Between Mutation and Selec...(2012-10-11)
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A pendulum model for genome compositional dynamics was demonstrated by a team led by Professor YU Jun and Professor ZHANG Zhang at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS).
In the published pap...