Group leader
Dr. YANG Yungui is a professor at Beijing Institute of Genomics, Chinese Academy of Sciences (CAS). Dr YANG received his BS degree in Microbiology from Fudan University in 1995 and PhD degree in Biochemistry and Molecular Biology from Shanghai Institute of Materia Medica/Shanghai Research Center of Biotechnology, CAS in 2000 with Dr. YANG Shengli . He performed his postdoctoral research in the laboratories of Dr WANG Zhaoqi (International Agency for Research on Cancer-IARC, 2000-2003) and Dr Tomas Lindahl (Nobel Laureate in Chemistry 2015; Clare Hall Laboratories, Cancer Research UK London Research Institute, 2005-2008). He had served as a staff scientist at IARC from 2003-2005. His research interest is to dissect the roles and biological significance of epitranscriptomic RNA modifications with focus on dynamic RNA methylations (i.e. N6-methyladenosine-m6A, 5-methylcytosine-m5C). He has totally published 36 corresponding- and 8 first-author papers in the peer-reviewed journals including Nature, Cell, Nature Cell Biol, Cell Stem Cell, Mol Cell, Cell Res, etc. He was elected as Member of the Academia Europaea in 2020
Introduction
Our research interests mainly focus on epitranscriptomic regulations and mechanisms of RNA methylation. We have contributed in a breakthrough point of expanding new research frontiers of RNA methylation-mediated epitranscriptomics by identifying the mammalian RNA N6-Methyladenosine (m6A) methyltransferase complex METTL3/METTL14/WTAP (Ping et al. Cell Research 2014), selective mechanism of m6A site (Chen et al. Cell Stem Cell 2015), m6A demethylases FTO (Jia et al. Nature Chemical Biology 2011) and ALKBH5 (Zheng et al. Molecular Cell 2013) and regulatory roles of m6A in mRNA splicing, translation and transcription (Zhao et al. Cell Research 2014; Xiao et al. Molecular Cell 2016; Li et al. Cell Research 2017; Yang et al. Cell Research 2018; Yang et al. Cell Research 2019). Our recent works further revealed that m6A modulates spermatogenesis, haematopoietic stem/progenitor cell specification, brain development and even cancer (Zhang et al. Nature 2017; Xu et al. Cell Research 2017; Zhang et al. Cell Research 2018; Jia et al. Molecular Cancer 2019; Wu et al. Cell Research 2019). We further involved in the identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation (Peng et al. Science Translational Medicine 2019). In addition, we uncovered the regulatory role of m5C in mediating mRNA export via its reader protein ALYREF (Yang et al. Cell Research 2017), and mRNA stabilization via its reader Ybx1 then regulating zebrafish maternal-to-zygotic transition (Yang et a. Molecular Cell 2019) and pathogenesis of bladder cancer (Chen et al. Nature Cell Biology 2019). We further mapped dynamic methylome of internal mRNA N7-methylguanosine (Malbec et al. Cell Research 2019). The discovery of the RNA methylation methyltransferases and demethylases demonstrate that the dynamic and reversible chemical modification on RNA is now considered a novel epitranscriptomic marker of profound biological significance.
Selected Publications
(*CORRESPONDING-AUTHOR EQUIVALENT)
1. Chen Yu-Sheng #, Lu Shuaiyao #, Zhang Bing #, Du Tingfu, Li Wen-Jie, Lei Meng, Zhou Yanan, Zhang Yong, Liu Penghui, Sun Yong-Qiao, Zhao Yong-Liang, Yang Ying*, Peng Xiaozhong*, Yang Yun-Gui*. Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome, Protein & Cell, 2021. https://doi.org/10.1007/s13238-021-00861-8
2. Zhang Ting#, Yang Ying#, Xiang Zichun#, Gao Chun-Chun#, Wang Wenjing, Wang Conghui, Xiao Xia, Wang Xing, Qiu Wei-Nan, Li Wen-Jie, Ren Lili, Li Mingkun, Zhao Yong-Liang, Chen Yu-Sheng*, Wang Jianwei*, and Yang Yun-Gui*. N6- methyladenosine regulates RNA abundance of SARS-CoV-2, Cell Discovery, 2021, 7(1): 7.
3. Mu Haiyuan #, Zhang Ting #, Yang Ying #, Zhang Danru, Li Junhong, Yue Liang, Gao Dengfeng, Shi Bingbo, Han Yue, Zhong Liang, Chen Xinze, Wang Zhen-Bo, Lin Zhen, Tong Minghan, Sun Qing-Yuan, and Gao Jie, Yang Yun-Gui*, Han Jianyong*. METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice. Cell Death and Differentiation. Accepted
4. Wu Gongwei# *, Suo Caixia#, Yang Ying, Shen Shengqi, Sun Linchong, Li Shi-Ting, Zhou Yingli, Yang Dongdong, Wang Yan, Cai Yongping, Wang Nana, Zhang Huafeng, Yang Yun-Gui*, Cao Jie* & Gao Ping*. MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation, EMBO Reports, 2021, e51519.
5. Li Yaqian#, Zhang Qing-Yang#, Sun Bao-Fa#, Ma Yidi, Zhang Ye, Wang Min, Ma Congcong, Shi Honghui, Sun Zhijing, Chen Juan, Yang Yun-Gui*, Zhu Lan*. Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse, Nature Communications, 2021, 12(1): 87.
6. Chen Yu-Sheng#, Yang Wen-Lan#, Zhao Yong-Liang, Yang Yun-Gui*. Dynamic transcriptomic m5C and its regulatory role in RNA processing, WIREs RNA, 2021, e1639, doi: 10.1002/wrna.1639.
7. Qiu Weinan#, Zhang Qingyang#, Zhang Rui, Lu Yangxu, Wang Xin, Tian Huabin, Yang Ying, Gu Zijuan, Gao Yanan, Yang Xin, Cui Guanshen, Sun Bao-Fa, Peng Yanan, Deng Hongyu, Peng Hua, Yang Angang, Yang Yun-Gui*, Yang Pengyuan*. N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA, Nature Communications, 2021, 12:1582, doi: 10.1038/s41467-021-21904-y.
8. Yao Yingpeng#, Yang Ying#, Guo Wenhui#, Xu Lifan#, You Menghao, Zhang Yi-Chang, Sun Zhen, Cui Xiao, Yu Guotao, Qi Zhihong, Liu Jingjing, Wang Fang, Liu Juanjuan, Zhao Tianyan, Ye Lilin*, Yang Yun-Gui* & Yu Shuyang*. METTL3-dependent m6A modification programs T follicular helper cell differentiation, Nature Communications, 2021, 12(1): 1333, doi: 10.1038/s41467-021-21594-6.
9. Shi Boyang#, Zhang Jinsong#, Heng Jian#, Gong Jing#, Zhang Ting, Li Pan, Sun Bao-Fa, Yang Ying, Zhang Ning, Zhao Yong-Liang, Wang Hai-Lin, Liu Feng*, Zhang Qiangfeng Cliff* and Yang Yun-Gui*. RNA structural dynamics regulates early embryogenesis through controlling transcriptome fate and function, Genome Biology, 2020, 21(1): 120.
10. Han Xiao#, Wang Mengke#, Zhao Yong-Liang, Yang Ying*, Yang Yun-Gui*. RNA methylations in human cancers, Seminars in Cancer Biology, 2020, S1044-579X(20)30241-8.
11. Tang Yongyan#, Gao Chun-Chun#, Gao Ying, Yang Ying, Shi Boyang, Yu Jia-Li, Lyu Cong, Sun Bao-Fa, Wang Hai-Lin, Xu Yunyuan, Yang Yun-Gui*, and Chong Kang*. OsNSUN2-mediated 5-methylcytidine mRNA modification enhances rice adaptation to high-temperature, Developmental Cell, 2020, 53: 272-286.
12. Han Xiao#, Liu Hanchen#, Zhang Zezhong#, Yang Wenlan, Wu Chunyan, Liu Xueying, Zhang Fang, Sun Baofa, Zhao Yongliang, Jiang Guibin, Yang Yun-Gui*, Ding Wenjun*. Epitranscriptomic 5-methylcytosine profile in PM2.5-induced mouse pulmonary fibrosis, Genomics, Proteomics& Bioinformatics, 2020, 18 (1) : 41-51.
13. Chen Xin#, Li Ang#, Sun Bao-Fa#, Yang Ying#, Han Ya-Nan#, Yuan Xun#, Chen Ri-Xin, Wei Wen-Su, Liu Yanchao, Gao Chun-Chun, Chen Yu-Sheng, Zhang Mengmeng, Ma Xiao-Dan, Liu Zhuo-Wei, Luo Jun-Hang, Lyu Cong, Wang Hai-Lin, Ma Jinbiao, Zhao Yong-Liang, Zhou Fang-Jian, Huang Ying*, Xie Dan* and Yang Yun-Gui*. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs, Nature Cell Biology, 2019, 21(8): 978-990.
14. Yang Ying#, Wang Lu#, Han Xiao#, Yang Wen-Lan#, Zhang Mengmeng#, Ma Hai-Li, Sun Bao-Fa, Li Ang, Xia Jun, Chen Jing, Heng Jian, Wu Baixing, Chen Yu-Sheng, Xu Jia-Wei, Yang Xin, Yao Huan, Sun Jiawei, Lyu Cong, Wang Hai-Lin, Huang Ying, Sun Ying-Pu, Zhao Yong-Liang, Meng Anming, Ma Jinbiao*, Liu Feng*, and Yang Yun-Gui*. RNA 5-methylcytosine facilitates the maternal-to-zygotic transition by preventing maternal mRNA decay, Molecular Cell, 2019, 75(6): 1188-1202.
15. Yang Xin#, Yang Ying#, Sun Bao-Fa#, Chen Yu-Sheng#, Xu Jia-Wei#, Lai Wei-Yi#, Li Ang, Wang Xing, Bhattarai Devi Prasad, Xiao Wen, Sun Hui-Ying, Zhu Qin, Ma Hai-Li, Adhikari Samir, Sun Min, Hao Ya-Juan, Zhang Bing, Huang Chun-Min, Huang Niu, Jiang Gui-Bin, Zhao Yong-Liang, Wang Hai-Lin*, Sun Ying-Pu*, Yang Yun-Gui*. 5-methylcytosine promotes mRNA export-NSUN2 as the methyltransferase and ALYREF as an m5C reader, Cell Research, 2017, 27(5): 606-625.
16. Zhang Chunxia#, Chen Yusheng#, Sun Baofa#, Wang Lu#, Yang Ying#, Ma Dongyuan, Lv Junhua, Heng Jian, Ding Yanyan, Xue Yuanyuan, Lu Xinyan, Xiao Wen, Yang Yun-Gui* & Liu Feng*. m6A modulates haematopoietic stem and progenitor cell specification, Nature, 2017, 549(7671): 273-276.
17. Xiao Wen#, Adhikari Samir#, Dahal Ujwal#, Chen Yu-Sheng#, Hao Ya-Juan#, Sun Bao-Fa#, Sun Hui-Ying, Li Ang, Ping Xiao-Li, Lai Wei-Yi, Wang Xing, Ma Hai-Li, Huang Chun-Min, Yang Ying, Huang Niu, Jiang Gui-Bin, Wang Hai-Lin, Zhou Qi, Wang Xiu-Jie, Zhao Yong-Liang, and Yang Yun-Gui*. Nuclear m6A reader YTHDC1 regulates mRNA splicing, Molecular Cell, 2016, 61(4): 507-519）
18. Shi Zhan#, Zhang Qingyang#, Yan Huige#, Yang Ying#, Wang Pingzhang, Zhang Yixiao, Deng Zhenling, Yu Meng, Zhou Wenjing, Wang Qianqian, Yang Xi, Mo Xiaoning, Zhang Chi, Huang Jing, Dai Hui, Sun Baofa, Zhao Yongliang, Zhang Liang, Yang Yun-Gui* and Qiu Xiaoyan*. More than one antibody of individual B cells revealed by single-cell immune profiling, Cell Discovery, 2019, 5:64, doi: 10.1038/s41421-019-0137-3.
19. Jia Ruobing#, Chai Peiwei#, Wang Shanzheng#, Sun Baofa, Xu Yangfan, Yang Ying, Ge Shengfang, Jia Renbing*, Yang Yun-Gui* and Fan Xianqun*. m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation, Molecular Cancer, 2019, 18(1):161.
20. Yang Xin#, Liu Qian-Lan#, Xu Wei#, Zhang Yi-Chang#, Yang Ying, Ju Lin-Fang, Chen Jing, Chen Yu-Sheng, Li Kuan, Ren Jie*, Sun Qianwen* and Yang Yun-Gui*. m6A promotes R-loop formation to facilitate transcription termination, Cell Research, 2019, 29(12):1035-1038.
21. Malbec Lionel#, Zhang Ting#, Chen Yu-Sheng#, Zhang Ying, Sun Bao-Fa, Shi Bo-Yang, Zhao Yong-Liang, Yang Ying* and Yang Yun-Gui*. Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation, Cell Research, 2019, 29(11): 927–941.
22. Peng Junya#, Sun Bao-Fa#, Chen Chuan-Yuan#, Zhou Jia-Yi#, Chen Yu-Sheng#, Chen Hao, Liu Lulu, Huang Dan, Jiang Jialin, Cui Guan-Shen, Yang Ying, Wang Wenze, Guo Dan, Dai Menghua, Guo Junchao, Zhang Taiping, Liao Quan, Liu Yi, Zhao Yong-Liang, Han Da-Li#, Zhao Yupei*, Yang Yun-Gui* and Wu Wenming*. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma, Cell Research, 2019, 29(9):725-738.
23. Peng Shiming#, Xiao Wen#, Ju Dapeng#, Sun Baofa#, Hou Nannan, Liu Qianlan, Wang Yanli, Zhao Haijiao, Gao Chunchun, Zhang Song, Cao Ran, Li Pengfei, Huang Huanwei, Ma Yongfen, Wang Yankai, Lai Weiyi, Ma Zhixiong, Zhang Wei, Huang Song, Wang Hailin, Zhang Zhiyuan, Zhao Liping, Cai Tao, Zhao Yong-Liang, Wang Fengchao, Nie Yongzhan, Zhi Gang, Yang Yun-Gui*, Zhang Eric Erquan*, Huang Niu*. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1, Science Translational Medicine, 2019, 11(488): eaau7116.
24. Wu Rong#, Li Ang#, Sun Baofa#, Sun Jian-Guang#, Zhang Jinhua#, Zhang Ting#, Chen Yusheng, Xiao Yujie, Gao Yuhao, Zhang Qingyang, Ma Jun, Yang Xin, Liao Yajin, Lai Wei-Yi, Qi Xiaolong, Wang Shukun, Shu Yousheng, Wang Hai-Lin, Wang Fengchao*, Yang Yun-Gui* and Yuan Zengqiang*. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination, Cell Research, 2019, 29(1): 23-41.
25. Yang Ying#, Hsu Phillip J.#, Chen Yu-Sheng and Yang Yun-Gui*. Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism, Cell Research, 2018, 28(6): 616-624.
26. Zhang Zeyu#, Wang Meng#, Xie Dongfang, Huang Zenghui, Zhang Lisha, Yang Ying, Ma Dongxue, Li Wenguang, Zhou Qi, Yang Yun-Gui* and Wang Xiu-Jie*. METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation, Cell Research, 2018, 28(11): 1050-1061.
27. Wang Chen-Xin#, Cui Guan-Shen#, Liu Xiuying#, Xu Kai#, Wang Meng#, Zhang Xin-Xin, Jiang Li-Yuan, Li Ang, Yang Ying, Lai Wei-Yi, Sun Bao-Fa, Jiang Gui-Bin, Wang Hai-Lin, Tong Wei-Min, Li Wei, Wang Xiu-Jie*, Yang Yun-Gui*, Zhou Qi*. Mettl3-mediated m6A modification is required for cerebellar development, PLOS Biology, 2018, 16(6):e2004880.
28. Tian Xin#, Sun Baofa#, Chen Chuanyuan#, Gao Chunchun#, Zhang Ji#, Lu Xingyu#, Wang Linchen, Li Xiangnan, Xing Yurong, Liu Ruijuan, Han Xiao, Qi Zheng, Zhang Xiaojian, He Chuan, Han Dali*, Yang Yun-Gui* and Kan Quancheng*. Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer, Cell Research, 2018, 28(5): 597-600.
29. Xu Kai#, Yang Ying#, Feng Gui-Hai#, Sun Bao-Fa#, Chen Jun-Qing#, Li Yu-Fei, Chen Yu-Sheng, Zhang Xin-Xin, Wang Chen-Xin, Jiang Li-Yuan, Liu Chao, Zhang Ze-Yu, Wang Xiu-Jie, Zhou Qi*, Yang Yun-Gui*, Li Wei*. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation, Cell Research, 2017, 27(9):1100-1114.
30. Li Ang#, Chen Yu-Sheng#, Ping Xiao-Li, Yang Xin, Xiao Wen, Yang Ying, Sun Hui-Ying, Zhu Qin, Baidya Poonam, Wang Xing, Bhattarai Devi Prasad, Zhao Yong-Liang, Sun Bao-Fa*, Yang Yun-Gui*. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation, Cell Research, 2017, 27(3): 444-447.
31. Chen Tong#, Hao Ya-Juan#, Zhang Ying#, Li Miao-Miao#, Wang Meng, Han Weifang, Wu Yongsheng, Lv Ying, Hao Jie, Wang Libin, Li Ang, Yang Ying, Jin Kang-Xuan, Zhao Xu, Li Yuhuan, Ping Xiao-Li, Lai Wei-Yi, Wu Li-Gang, Jiang Guibin, Wang Hai-Lin, Sang Lisi, Wang Xiu-Jie*, Yang Yun-Gui*, and Zhou Qi*, m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell, 2015, 16(3): 289-301.
32. Ping Xiao-Li#, Sun Bao-Fa#, Wang Lu#, Xiao Wen#, Yang Xin, Wang Wen-Jia, Adhikari Samir, Shi Yue, Lv Ying, Chen Yu-Sheng, Zhao Xu, Li Ang, Yang Ying, Dahal Ujwal, Lou Xiao-Min, Liu Xi, Huang Jun, Yuan Wei-Ping, Zhu Xiao-Fan, Cheng Tao, Zhao Yong-Liang, Wang Xinquan, Rendtlew Danielsen Jannie M, Liu Feng*, Yang Yun-Gui*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase, Cell Research, 2014, 24(2): 177-189.
33. Zhao Xu#, Yang Ying#, Sun Bao-Fa#, Shi Yue#, Yang Xin, Xiao Wen, Hao Ya-Juan, Ping Xiao-Li, Chen Yu-Sheng, Wang Wen-Jia, Jin Kang-Xuan, Wang Xing, Huang Chun-Min, Fu Yu, Ge Xiao-Meng, Song Shu-Hui, Jeong Hyun Seok, Yanagisawa Hiroyuki, Niu Yamei, Jia Gui-Fang, Wu Wei, Tong Wei-Min, Okamoto Akimitsu, He Chuan, Rendtlew Danielsen Jannie M, Wang Xiu-Jie, Yang Yun-Gui*. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis, Cell Research, 2014, 24(12): 1403-1419.
34. Zheng Guanqun#, Dahl John Arne#, Niu Yamei#, Fedorcsak Peter, Huang Chun-Min, Li Charles J., V?gb? Cathrine B., Shi Yue, Wang Wen-Ling, Song Shu-Hui, Lu Zhike, Bosmans Ralph P.G., Dai Qing, Hao Ya-Juan, Yang Xin, Zhao Wen-Ming, Tong Wei-Min, Wang Xiu-Jie, Bogdan Florian, Furu Kari, Fu Ye, Jia Guifang, Zhao Xu, Liu Jun, Krokan Hans E., Klungland Arne*, Yang Yun-Gui*, and He Chuan*. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility, Molecular Cell, 2013, 49(1): 18-29.
35. Gao Min#, Wei Wei#, Li Ming-Ming#, Wu Yong-Sheng#, Ba Zhaoqing, Jin Kang-Xuan, Li Miao-Miao, Liao You-Qi, Adhikari Samir, Chong Zechen, Zhang Ting, Guo Cai-Xia, Tang Tie-Shan, Zhu Bing-Tao, Xu Xing-Zhi, Mailand Niels, Yang Yun-Gui*, Qi Yijun*. Rendtlew Danielsen Jannie M, Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination, Cell Research, 2014, 24(5): 532-541.
36. Zhao Bailin#, Yang Ying#, Wang Xiaoli#, Chong Zechen, Yin Ruichuan, Song Shu-Hui, Zhao Chao, Li Cuiping, Huang Hua, Sun Bao-Fa, Wu Danni, Jin Kang-Xuan, Song Maoyong, Zhu Ben-Zhan, Jiang Guibin, Rendtlew Danielsen Jannie M., Xu Guo-Liang, Yang Yun-Gui*, Wang Hailin*. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism, Nucleic Acids Research, 2014, 42(3):1593-1605.
37. Li Ming-Ming#, Nilsen Anja#, Shi Yue#, Fusser Markus, Ding Yue-He, Fu Ye, Liu Bo, Niu Yamei, Wu Yong-Sheng, Huang Chun-Min, Olofsson Maria, Jin Kang-Xuan, Lv Ying, Xu Xing-Zhi, He Chuan, Dong Meng-Qiu, Rendtlew Danielsen Jannie M., Klungland Arne* & Yang Yun-Gui*. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics, Nature Communications, 2013, 4: 1832.
38. Gao Min#, Rendtlew Danielsen Jannie#, Wei Lei-Zhen#, Zhou Dong-Ping, Xu Qian, Li Miao-Miao, Wang Zhao-Qi, Tong Wei-Min, Yang Yun-Gui*. A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity, PLoS ONE, 2012, 7(11): e49687.
39. Adhikari Samir, Xiao Wen, Zhao Yong-Liang, and Yang Yun-Gui*. m6A: Signaling for mRNA Splicing, RNA Biology, 2016, 13(9): 756-759.
40. Yang Ying#, Sun Bao-Fa#, Xiao Wen, Yang Xin, Sun Hui-Ying, Zhao Yong-Liang, Yang Yun-Gui*. Dynamic m6A modification and its emerging regulatory role in mRNA splicing, Science Bulletin, 2015, 60(1): 21-32.
41. Klungland Arne*, Yang Yun-Gui*. Endogenous DNA damage and repair enzymes, Genomics, Proteomics & Bioinformatics, 2016, 14(3): 122-125.
42. Mi Shuangli, Klungland Arne* & Yang Yun-Gui*. Base-excision repair and beyond, Science China Life Sciences, 2016, 59(1): 89-92.
43. Yang Yun-Gui*, Qi Yijun*. RNA-directed repair of DNA double-strand breaks, DNA Repair, 2015, 32: 82-85.
44. Zhao Xu#, Yang Ying#, Sun Bao-Fa, Zhao Yong-Liang, Yang Yun-Gui*. FTO and obesity: mechanisms of association, Current Diabetes Reports, 2014, 14(5): 486.
45. Niu Yamei, Zhao Xu, Wu Yong-Sheng, Li Ming-Ming, Wang Xiu-Jie, Yang Yun-Gui*. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function, Genomics, Proteomics & Bioinformatics, 2013, 11(1): 8-17.
Awards and Honors
2020: Member of the Academia Europaea
2019: Jiazhen Tan Life Science Innovation Award, China Association for Science and Technology Life Science Consortium
2019: Excellent Supervisor Award, Chinese Academy of Sciences
2018: Expert with Special Government Allowance from the State Council, China
2018: Excellent Supervisor Award, Chinese Academy of Sciences
2017: Top 10 Life Science Advances of China
2017: Sanofi-Cell Research Outstanding Paper Award
2016: The National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China
2013: Zhu Li Yuehua Award for Outstanding Teacher, Chinese Academy of Sciences
2012: The International Cooperation Award for Young Scientists, Chinese Academy of Sciences
2012: University of the Chinese Academy of Sciences - BHPB Mentor Research Award
Professional Activities
2019: Member of the Phenotypic Committee, the Chinese Society of Biophysics
2019: Member of the Academic Advisory Committee, the First Affiliated Hospital of Zhengzhou University
2018: Member of the Stem Cell Biology Committee, the Chinese Society of Cell Biology
2018: RNA Biology-Editorial Board
2018: Deputy Secretary-General, the 12th Council of the Chinese Society of Biochemistry and Molecular Biology, China
2017: Director of the Fourth Scientific Advisory Committee, Beijing Institute of Genomics, Chinese Academy of Sciences
2017: Member of the Academic Advisory Board, the State Key Laboratory of Molecular Biology
2017: Member of Chromatin Biology Committee, China Society of Cell Biology
2016: Member of the Science and Technology Committee, the National Center for Molecular Medicine Transformation Science, China
2016: Deputy Director of RNA Society of the Chinese Society of Biochemistry and Molecular Biology, China
2016: Journal of Genetics and Genomics-Editorial Board
2015: Genomics, Proteomics & Bioinformatics-Editorial Board and Associate Chief Editor
2015: Deputy Director of Department of Biochemistry, College of Life Sciences, University of Chinese Academy of Sciences
2015: Head of Education Program Omics Division, Sino-Danish College, University of Chinese Academy of Sciences
2014: Deputy Director of Department of Epigenetics, Collaborative Innovation Center for Genetic and Development, Fudan University
2010: DNA Repair-Editorial Board
Staff
Dr. SUN Baofa, Associate professor, sunbf@big.ac.cn
Dr. YANG Ying, Associate professor, yingyang@big.ac.cn
Dr. CHEN Yusheng, Special research assistant, Chenysh@big.ac.cn
Ms. HUANG Chunmin, Engineer, huangchm@big.ac.cn
Ms. XUAN Chen, Engineer, xuanchen@big.ac.cn
Post-doctors
Dr. ZHANG Li-Yuan, zhangly@big.ac.cn
Graduate Students
SHI Boyang,2016
MALBEC Lionel, 2016
CUI Guanshen, 2016
GAO Chunchun, 2016
YANG Wenlan, 2016
YAO Huan, 2016
LIU Qianlan, 2016
AN Ke, 2016
SONG Dang, 2016
WANG Xiuzhi, 2017
ZHANG Ting, 2017
HAN Xiao, 2017
ZHANG Qingyang, 2017
GE Xinyang, 2017
HAN Yue, 2017
WANG Shanzheng, 2017
JU Linfang, 2017
CHEN Jing, 2018
GUO Jingyun, 2018
ZHOU Jiayi, 2018
LIANG Chengzhi, 2018
PU Junming, 2018
