Group leader
Dr. WANG Qianfei "Jeffrey" is currently a professor and the Director of CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). He is also a joint professor at the State Key Laboratory of Experimental Hematology and a member of the 13th and 14th expert committee in Medical Sciences of National Natural Science Foundation of China. He was awarded the National Science Fund for Distinguished Young Scholars in 2014.
Dr. WANG received his bachelor degree in clinical medicine from Shandong Medical University in China. He then earned his Ph.D. from Johns Hopkins University School of Medicine in 2002 (thesis advisors: Drs. Mark Schlissel and Alan Friedman). Under the supervision of Dr. Edward Rubin, Dr. WANG pursued his postdoctoral training in the Genomics Division at Lawrence Berkeley National Laboratory, University of California, Berkeley. Before Dr. WANG joined the faculty at Beijing Institute of Genomics, he was an Assistant Professor (Research Associate) at Section of Hematology/Oncology, the University of Chicago (2007-2009). Dr. WANG's background in clinical medicine, experimental biology and genomics has provided him with a unique opportunity to decipher the molecular mechanism and regulatory network controlling hematopoiesis and the development of human leukemia.
Introduction
Leukemia is a malignant disease characterized by the uncontrolled accumulation of blood cells. Leukemia causes more deaths than any other cancer among children and young adults under the age of 20. Despite multi agent chemotherapy and stem cell transplantation, the overall survival rate of acute myeloid leukemia is less than 30%.
Through integrative programs combining biochemistry, cellular/molecular biology, and powerful genomics technology platforms, we seeks to transform original raw genomics data and basic research insights into knowledges of precision medicine related to AML diagnosis and treatment. Our lab has employed a combined genomic and functional characterization strategy to:
1) Integrative genomic and functional analysis of acute leukemia
2) Genomic and clinical study of clonal evolution in human leukemia
3) Megakaryocytes and platelets: Development and in vitro regeneration from stem cells
Selected Publications
1. Li JJ, Liu JK, Li YQ, Chen, Cheng H*, Li YY*, Cheng T *, Wang QF*, Zhou B*. Differentiation route determines the functional outputs of adult megakaryopoiesis. Immunity. (Accepted)
2. Zhang YP, Jiang ST, He FH, Tian YY, Hu HY, Gao L, Zhang L, Chen AL, Hu YX, Fan LY, Yang C, Zhou B, Liu D, Zhou ZH, Su YX, Qin L, Wang Y, He HL, Lu J, Xiao PF, Hu SY*, Wang QF*. Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML.Genome Biology. 2023 Aug 31;24(1):199. doi: 10.1186/s13059-023-03031-7.
3. Luo H, Liu D, Liu WB, Jin J, Bi XM, Zhang PL, Gu J, Zheng M, Xiao M, Liu X, Zhou JF*, Wang QF*. Clinical and genetic characterization of Epstein-Barr virus-associated T/NK-cell lymphoproliferative diseases. J Allergy Clin Immunol. 151(4):1096-1109, 2023
4. Wang QF*, Zhu HH*. APL: Nemo finds its sea anemone. Blood. 140(22):2311-2312, 2022
5. Bi XM, Zhang Q, Chen L, Liu D, Li YY , Zhao XX, Zhang Y, Zhang LP, Liu JK, Wu CY, Li ZG, Zhao YZ, Ma HH, Huang G, Liu X*, Wang QF*, Zhang R*. NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis. J Hematol Oncol. 2022 Jul 28;15(1):101. doi: 10.1186/s13045-022-01318-z.
6. Sun S, Jin C, Si J, Lei Y, Chen KY, Cui YL, Liu ZB, Liu J, Zhao M, Zhang XH, Tang FC, Rondina MT, Li YY*, Wang QF*. Single-cell analysis of ploidy and transcriptome reveals functional and spatial divergency in murine megakaryopoiesis. Blood. 138(14):1211-1224, 2021
7. Luo H, Liu D, Liu WB, Wang GX, Chen LT, Cao Y, Wei J, Xiao M, Liu X, Huang G, Wang W*, Zhou JF*, Wang QF*. Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms. Eur J Hum Genet. 29(8):1312-1315, 2021
8. Zhao JX, Sui PP, Wu B, Chen AL, Lu YD, Hou LF, Cheng XR, Cui SW, Song JY, Huang G, Xing CH* and Wang QF*. Benzene induces rapid leukemic transformation after prolonged hematotoxicity in a murine model. Leukemia. 35(2):595-600, 2021
9. Hu YX, Chen AL , Zheng XC, Lu J, He HL, Yang J, Zhang Y, Sui PP, Yang JY, He FH, Wang Y, Xiao PF, Liu X, Zhou YM, Pei DQ, Cheng C, Ribeiro R C*, Hu SY* and Wang QF*. Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy. National Science Review. 6(3): 469–479, 2019
10. Zhang P , He FH, Bai J, Yamamoto S, Chen S, Zhang L, Sheng MY, Zhang L, Guo Y, Man N, Yang H, Wang SY, Cheng T, Nimer SD, Zhou Y, Xu MJ*, Wang QF* and Yang FC*. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. J Clin Invest. 128(12):5383-5398,2018
11. Yang XJ, Lu B, Sun XQ, Han CJ, Fu CL, Xu KL, Wang M, Li DJ, Chen ZC, Opal P, Wen Q, Crispino JD, Wang QF*, Huang Z*. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia. 32(7):1587-1597,2018
12. Bu JC, Chen AL, Yan XM, He FH, Dong YZ, Zhou YL, He JL, Zhan D, Lin PP, Hayashi Y, Sun YL, Zhang Y, Xiao ZJ, Grimes HL, Wang QF* and Huang G*. SETD2 mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. Leukemia.32(4):890-899，2018
13. Li YY, Jin C, Bai H, Gao YX, Sun S, Chen L, Qin L, Liu PP, Cheng LZ*, Wang QF*. Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation. Blood. 131(2):191-201,2018
14. Huang L, Liu D, Wang N, Ling SP, Tang YT, Wu J, Hao LT, Luo H, Hu XL, Sheng LS, Zhu LJ, Wang D, Luo Y, Shang Z, Xiao M, Mao X, Zhou KG, Cao LH, Dong LL, Zheng XC, Sui PP, He JL, Mo SL, Yan J, Ao QL, Qiu LG, Zhou HS, Liu QF, Zhang HY, Li JY, Jin J, Fu L, Zhao WL, Chen JP, Du X, Qing GL, Liu HD, Liu X, Huang G, Ma D, Zhou JF*, Wang QF*. Integrated Genomic Analysis Identifies Deregulated JAK/STAT-MYC-Biosynthesis Axis in Aggressive NK-cell Leukemia.Cell Research. 28(2):172-186, 2018
15. Li JP, He FH, Zhang P, Chen S, Shi H, Sun YL, Guo Y, Yang H, Man N, Greenblatt S, Li ZM, Guo ZY, Zhou Y, Wang L, Morey L, Williams S, Chen X, Wang QT, Nimer S, Yu P, Wang QF*, Xu MJ* and Yang FC*. Loss of Asxl2 leads to myeloid malignancies in mice. Nature Communications. 2017 Jun 8;8:15456. doi: 10.1038/ncomms15456
16. Zhang P, Xing CH, Rhodes SD, He YZ, Deng K, Li ZM, He FH, Zhu CY, Nguyen L, Zhou Y, Chen S, Mohammad K S, Guise TA, Abdel-Wahab O, Xu MJ, Wang QF* and Yang FC*. Loss of asxl1 alters self-renewal and cell fate of bone marrow stromal cell, leading to Bohring-Opitz-like syndrome in Mice. Stem Cell Reports. 6(6):914-925,2016
17. Cai J, Miao XX, Li YY, Smith C, Tsang K, Cheng LZ* and Wang QF*. Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells. Stem Cell Reports. 3(2):227-233,2014
18. Zhu XF, He FH, Zeng HM, Ling SP, Chen AL, Wang YQ, Yan XM, Wei W, Pang YK, Cheng H, Hua CL, Zhang Y, Yang XJ, Lu X, Cao LH , Hao LT, Dong LL, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang LX , Mi SL, Wang XJ, Zhang L, Zou Y, Chen YM, Geng Z, Zhou JF, Wang JM, Liu X, Wang JX, Yuan WP, Huang G*, Cheng T* and Wang QF*. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nature Genetics. 46(3): 287-293,2014
19. Zhou J, Wu J, Li B, Liu D, Yu J, Yan XM, Zheng S, Wang JG, Zhang LX, Zhang L, He FH, Li Q, Chen AL, Zhang Y, Zhao XH, Guan YH, Zhao XH, Yan J, Ni J, Nobrega M, L？wenberg B, Delwel R, Valk P J, Kumar A, Xie L, Tenen DG, Huang G* and Wang QF*. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia. 28(7): 1436-1448, 2014
20. Wang QF*, Li YJ, Dong JF, Li B, KaberleinJJ, Zhang L, Arimura FE, Luo RT, Ni J, He FH, Wu J, Mattison R, Zhou J, Wang CZ, Prabhakar S, Nobrega M A and Thirman M J*. Regulation of MEIS1 by distal enhancer elements in acute leukemia. Leukemia. 28(1):138-146,2014
21. Wang QF, Wu G, Mi SL, He FH, Wu J, Dong JF, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji HK and Thirman MJ. MLL fusion proteins preferentially regulate a subset of wild type MLL target genes in the leukemic genome. Blood. 117(25):6895-6905,2011
Patents
1.Wang Qianfei, Cheng Linzhao, Li Yueying, Medical Use of NOTCH4 or Inhibitors Thereof, 2019.3.8,China, ZL 201610928867.2
2.Cheng Tao, Wang Qianfei, Zhu Xiaofan, Yuan Weiping, Assay kit for detecting mutations in the SETD2 gene (SETD2), 2015.3.11, China, ZL 201310107889.9
Awards and Honors
2014 The National Science Fund for Distinguished Young Scholars
2015 Zhu Liyuehua Excellent Teacher Award
2015 National Hundred, Thousand and Ten Thousand Talents Project
2016 State Council Expert for Special Allowance
Group Members
Staff:
LI Yueying: Professor (Experimental biology)
HE Fuhong: Associate professor(Bioinformatics)
CHEN Aili: Associate professor (Experimental biology)
LIU Dan: Research assistant professor(Bioinformatics)
YAN Jin: Research assistant
ZHANG Ya: Specialized Research Associate (Experimental biology)
JIANG Shuting: Specialized Research Associate (Bioinformatics)
LEI Ying：Specialized Research Associate (Experimental biology)
Graduate Students：
2017
QIN Lei
2018
SI Jia, LIU Jingkun, HU Haiyang, Yi Zhenyi
2019
SU Yanxun, YAN Lina, CHEN Kunying
2020
XIA Mengfang, HE Xudong, ZHANG Jie
2021
CHEN Qiyi
2022
LIU Yu, LIU Yukuan, WANG Liping, YAO Shijie
