Introduction
Our contributions to the field of science are multifaceted and groundbreaking. Firstly, we achieved the assembly of the diploid reference genome for the Han Chinese (T2T-YAO), surpassing the quality of the latest human reference genome T2T-CHM13 released by the US-NIH, positioning it as the world's top reference. Secondly, we developed a human microbiome analysis tool—VTwins, renowned for its precision in identifying mechanism-associated microorganisms. Additionally, in the field of medical genomic research, we collaborate with esteemed institutions such as Peking University People’s Hospital, School of Basic Medicine, Institute of Mental Health, and Peking Union Medical College Hospital. This collaborative effort has led to groundbreaking insights into the novel pathogenesis of conditions such as autism, schizophrenia, rheumatoid arthritis, and food allergy. The fruits of these endeavors have been disseminated through publications in esteemed journals such as Science Advances, Nucleic Acid Research, Science Bulletin, Briefings in Bioinformatics, GPB, BMC Medicine, Lab on Chip, and other professional publications. Currently, Dr. KANG Yu's research group is at the forefront of two primary research directions: the dry experiment part involves the analysis of multi-omics data, tool and database development, and the discovery of disease-related genetic loci and markers using clinical and multi-omics big data. Simultaneously, the wet experiment part focuses on advancing sequencing and genetic analysis technologies. Dr. KANG's commitment to advancing knowledge and technology is evident in the continued innovation and impact of her research group.
Group leader
Dr. KANG Yu serves as a principal investigator at the Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). Holding a Ph.D. and a bachelor's degree from Peking University, she completed her postdoctoral training under the guidance of Prof. Jun Yu at BIG in 2012, subsequently assuming the role of assistant professor at the institute. Dr. KANG's research endeavors are centered around medical genomics, specializing in sequencing and analysis technologies for the human genome and metagenome. She has secured funding from prestigious sources, including the National Key Research and Development Program of China and the Natural Science Foundation of China, underscoring her commitment to advancing cutting-edge genomic research.
Selected Publications
#co-first authors. * co-correspondence
1.Meng Q, Zhou Q, Shi S, Xiao J, Ma Q, Yu J, Chen J, Kang Y. VTwins: inferring causative microbial features from metagenomic data of limited samples. Science Bulletin,2023 Oct 28,S2095-9273(23)00724-7, doi: 10.1016/j.scib.2023.10.024, Online ahead of print.PMID: 37919157.
2. He Y, Chu Y, Guo S, Hu J, Li R, Zheng Y, Ma X, Du Z, Zhao L, Yu W, Xue J, Bian W, Yang F, Chen X, Zhang P, Wu R, Ma Y, Shao C, Chen J, Wang J, Li J, Wu J, Hu X, Long Q, Jiang M, Ye H, Song S, Li G, Wei Y, Xu Y, Ma Y, Chen Y, Wang K, Bao J, Xi W, Wang F, Ni W, Zhang M, Yu Y, Li S, Kang Y, Gao Z. T2T-YAO: A Telomere-to-telomere Assembled Diploid Reference Genome for Han Chinese. Genomics Proteomics Bioinformatics, 2023 Aug 16,S1672-0229(23)00100-6, doi: 10.1016/j.gpb.2023.08.001, Online ahead of print.PMID: 37595788.
3.Chu Y, Meng Q, Yu J, Zhang J, Chen J, Kang Y. Strain-Level Dynamics Reveal Regulatory Roles in Atopic Eczema by Gut Bacterial Phages. Microbiology spectrum 2023 Mar 23;e0455122. doi: 10.1128/spectrum.04551-22.
4.Tong Z, Zhou X, Chu Y, Zhang T, Zhang J, Zhao X, Wang Z, Ding R, Meng Q, Yu J, Wang J, Kang Y. Implications of oral streptococcal bacteriophages in autism spectrum disorder. NPJ biofilms and microbiomes 2022, 8 (1), 91. DOI 10.1038/s41522-022-00355-3.
5.He J, Chu Y, Li J, Meng Q, Liu Y, Jin J, Wang J, Shi L, Shi X, Tian J, Xiao W, Gan Y, Guo J, Shao C, Mu R, Su Y, Hu F, Sun X, Yu J*, Kang Y*, Li Z*. Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis. Science Advances 2022, 8 (6), eabm1511. DOI 10.1126/sciadv.abm1511.
6.Liang Y, Shi X, Shen Y, Huang Z, Wang J, Shao C, Chu Y, Chen J, Yu J, Kang Y*. Enhanced Intestinal Protein Fermentation in Schizophrenia. BMC Medicine 2022 Feb 9,20(1):67.
7.Meng Q, Chu Y, Shao C, Chen J, Wang J, Gao Z*, Yu J*, Kang Y*. Role of Host Small RNAs in the Evolution and Host Tropisms of Coronaviruses. Briefings in Bioinformatics 2021,22(2):1096-1105
8.Kang, Y#., Yuan, L., Shi, X., Chu, Y., He, Z., Jia, X., Lin, Q., Ma, Q., Wang, J., Xiao, J., Hu, S., Gao, Z*., Chen, F*., Yu, J*., A fine-scale map of genome-wide recombination in divergent Escherichia coli population. Briefings in bioinformatics 2021 Jul 20,22(4):bbaa335
9.Zhang MX, Chu YN, Meng QR, Ding R, Shi X, Wang ZQ, He Y, Zhang J, Liu J, Zhang J, Yu J, Kang Y*, Wang J*. Impaired detoxification in the intestinal microbiome among children with autism spectrum disorder. Science Advances 2020, 6 (43), eaba3760.
10.Lyu W, Meng Q, Xiao J, Li J, Wang J, Qiu Z, Song X, Zhu H, Shao C, Chu Y, Zhou Q, Li T, Jean-Pierre R, Yu J, Han Y*, Kang Y*. Gut lactate-producing bacteria promote CD4 T cell recovery on Anti-retroviral therapy in HIV-infected patients. Computational Structural Biotechnology Journal. 2021,19:2928-2937.
11.Shi X, Gao Z, Lin Q, Zhao L, Ma Q, Kang Y*, Yu J*. Meta-analysis Reveals Potential Influence of Oxidative Stress on the Airway Microbiomes of Cystic Fibrosis Patients. Genomics Proteomics Bioinformatics. 2019 Dec,17(6):590-602.
12.Muhammad Ramzan Manwar SC, Shi Xing, Wang Jian, Lin Qiang, Tong Yigang, Kang Yu*, Yu Jun*. The Bacterial RNA Ligase RtcB Accelerates the Repair Process of Fragmented rRNA upon Releasing the Antibiotic Stress. Sci China Life Sci. 2019 Jun 26. doi: 10.1007/s11427-018-9405-y.
13.Shi X, Shao C, Luo C, Chu Y, Wang J, Meng Q, Yu J, Gao Z*, Kang Y*. Microfluidics-Based Enrichment and Whole-Genome Amplification Enable Strain-Level Resolution for Airway Metagenomics. mSystems. 2019 May 21,4(4). pii: e00198-19. doi: 10.1128/mSystems.00198-19.
12.Wu T, Shao C, Li L, Wang S, Ouyang Q, Kang Y*, Chunxiong Luo*. Streamline-based purification of bacterial samples from liquefied sputum utilizing microfluidics. Lab Chip 2017,17:3601-8.
13.Zhu L#, Zhong J#, Jia X#, Liu G#, Kang Y#, Dong M, Zhang X, Li Q, Yue L, Li C, Fu J, Xiao J, Yan J, Zhang B, Lei M, Chen S, Lv L, Zhu B, Huang H, Chen F. Precision methylome characterization of Mycobacterium tuberculosis complex (MTBC) using PacBio single-molecule real-time (SMRT) technology. Nucleic Acids Res. 2016 Jan 29,44(2):730-43
Patent
2020112896129. A RNA exonuclease nanopore complex and its preparation and application. KANG Yu, SHAO Changjun, YU Jun, CHU Yanan, CHEN Jing
2019108270919. A chip for separation bacteria and cells from body fluids and its preparation and application. SHAO Changjun, KANG Yu, SHI Xing, CHU Yanan, WANG Jian, MENG Qingren, YU Jun
2019106264595. Intestinal microbiota for evaluating the status and prognosis of rheumatoid arthritis. CHU Yanan, KANG Yu, MENG Qingren, YU Jun, SHI Xing, SHAO Changjun, WANG Jian, CHEN Jing
2018107456333. A Rapid Purification Reagent for Sputum Microorganisms and Its Application. SHAO Changjun, KANG Yu, SHI Xing, YU Jun, LIN Qiang, CHU Yanan, FU Rongrong
2017102884710. A Rapid Purification Device and Method for Pathogenic Bacteria in Sputum Samples. KANG Yu, SHAO Changjun, YU Jun, LIN Qiang, CHU Yanan, FU Rongrong
Group Members
Staff
Dr. CHU Yanan, Assistant Professor
Mr. SHAO Changjun, Engineer
Mr. WANG Jian, Engineer
Ms. CHEN Jing, Assistant Professor
Graduate Students
HUANG Zhuo
ZHANG Ruiyang
