Introduction
The Xudong Xing research team pioneers the innovative application of bioinformatics theories, methodological frameworks, and integrated technical systems to address frontier challenges of biomedicine. The team’s research centers on “Intelligent Computational Decoding and Prediction of Tumor Trajectory”, aiming to accelerate the translational development of novel cancer treatment strategies. Lab members pursue multidisciplinary research to uncover how complex molecular circuits are organized, regulated, and reshaped by genetic and environmental influences, cellular differentiation, and disease.
In recent years, they have published 10 articles in top-tier journals, including Nature (2024), Cancer Cell (2025, 2024), Science Immunology (2023), Science Translational Medicine (2022), Science Advances (2021), and Nature Immunology (2020). These studies have received over 3,300 citations, with four papers designated as ESI Top 1% Highly Cited Papers. The team’s work has been highlighted in leading journals, including Cancer Cell (two articles), Nature Reviews Clinical Oncology, and Cancer Discovery.
Group leader
1. XING Xudong
2. Biography
2026.01—Present, Professor，Beijing Institute of Genomics, CAS（China National Center for Bioinformation）
2024.10-2026.01, Principle Investigator，Beijing Institute of Genomics, CAS（China National Center for Bioinformation）
2021.07-2024.09, BoYa Postdoctoral Researcher, Peking University
2016.09-2021.07, Ph.D., Tsinghua University
2011.09-2016.07, BS, Harbin Medical University
3. Introduction
Dr. Xing is currently serving as a professor at China National Center for Bioinformation. He received his Ph.D. in Biology & Bioinformatics from Tsinghua University in 2021. Dr. Xing's research encompasses diverse areas, including single-cell omics, cancer genomics, cancer neuroscience, and immuno-informatics. His primary research focuses on “Intelligent Computational Decoding and Prediction of Tumor Trajectory”, including:
(1) Developing Artificial Intelligence Algorithms to Empower Early Cancer Detection and Intervention (Science Advances, 2021; Science Translational Medicine, 2022; Science Immunology, 2023).
(2) Establishing Analytical Frameworks to Identify Hallmarks of Advanced Tumor Progression (Cancer Cell, 2024; Cancer Cell, 2025).
(3) Building Data Models and Platforms to Decipher Sex Differences in Complex Diseases (Nature 2024; Nature Immunology 2020)
Dr. Xing currently serves as Principal Investigator of several nationally research programs, including the National Key R&D Program of China, the Sponsored by Beijing Nova Program, and the National Natural Science Foundation of China.
Research Fields
1. Biomedicine
2. Single-cell Omics
3. Bioinformatics
Selected Publications
1. Xudong Xing#, Jian Zhong#, Jana Biermann#, Hao Duan#, Xinyu Zhang#, Yu Shi#, ... , Yonggao Mou*, Benjamin Izar*, Nu Zhang*, Fan Bai*，Pan-cancer human brain metastases atlas at single-cell resolution，Cancer Cell 43 (2025), 1-19 （Highlighted in Cancer Cell and Cancer Discovery）
2. Fei Li#, Xudong Xing#, Qiqi Jin#, Xiang-Ming Wang#, Pengfei Dai#, Ming Han#, ... , Chen Yu*, Luonan Chen*, Fan Bai*, Dong Gao*,Sex differences orchestrated by androgens at single-cell resolution, Nature 629 (2024), 193-200 （ESI Top 1% Highly Cited Paper）
3. Jian Zhong#, Xudong Xing#, Yixin Gao#, ... , Fan Bai*, Nu Zhang*, Distinct roles of TREM2 in central nervous system cancers and peripheral cancers, Cancer Cell 42 (2024), 968-984 （Highlighted in Cancer Cell; Cell Press 2024 China Annual Papers in Life Sciences）
4. Xudong Xing#, Fan Yang#, ... , Mantang Qiu*,Fan Bai*, Jun Wang*, Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing, Science Advances 7 (2021), eabd9738 （ESI Top 1% Highly Cited Paper）
5. Jie-Feng Yang#, Xudong Xing#, Li Luo#, Xin-Wei Zhou#, ... , Hui Han*, Fan Bai*, Song Gao*, Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8 + T cell metabolic fitness and function in tumors, Science Immunology 8 (2023), abq2424
6. Guangxi Wang#, Mantang Qiu#, Xudong Xing#, ... , Jun Wang*, Yuxin Yin*, Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis, Science Translational Medicine 14 (2022), eabk2756 （ESI Top 1% Highly Cited Paper、Highlighted in Nature Reviews Clinical Oncology）
7. Ji-Yuan Zhang#, Xiang-Ming Wang#, Xudong Xing#, Zhe Xu#, ... , Fan Bai*, Fu-Sheng Wang*, Single-cell landscape of immunological responses in patients with COVID-19, Nature Immunology 21 (2020), 1107-1118 （ESI Top 1% Highly Cited Paper）
(# indicates equal contributed first authors; *indicates corresponding or co-corresponding authors)
Patent
1. A Method for Analyzing T-Cell Receptor Characteristics of T Lymphocytes Based on Single-Cell Multi-Omics Sequencing (ZL 2021 1 1213369.7)
2. A Method for Analyzing B-Cell Receptor Characteristics of B Lymphocytes Based on Single-Cell Multi-Omics Sequencing (ZL 2021 1 1374293.6)
Group Members
SHI Xiaoyu，Postdoctoral fellow
WANG Biying，Research Assistant
LIU Yukuan，PhD student
LI Rui，PhD student
ZHANG Zhipeng，PhD student
FU Hongyu，Msc student
LI Xize, Msc student
XU Xue, Msc student
Awards and Honors
Sponsored by Beijing Nova Program - 2025
Contact or Others
xingxd@big.ac.cn
