Introduction
Our group focuses on bioinformatics big data, engaging in the development of bioinformatics tools and methodologies, the integration and mining of multi-omics data, and the construction of bioinformatics databases, while also developing AI large models and intelligent agents for bioinformatics data analysis.
Group leader: ZHAO Wenming
Biography
2018.05—Present, professor，Beijing Institute of Genomics, CAS（China National Center for Bioinformation）
2011.12—2018.05 Associate professor，Beijing Institute of Genomics, CAS
2008.04—2011.12 Assistant professor，Beijing Institute of Genomics, CAS
About Group Leader
ZHAO Wenming graduated from Beihang University in 2008 in Computer Science, and then joined the Beijing Institute of Genomics (BIG) of the Chinese Academy of Sciences to engage in research on bioinformatics and big data. He led the establishment of the Genomics Science Archive (GSA), a biological omics data archiving system, which has become the largest public platform for biological data storage and management in China. GSA has been selected as the "Global Core Biological Data Resource", He published more than 60 papers, and he won the Excellent Scientific Paper Award of the 8th Excellent Scientific Paper Selection Plan of the China Association for Science and Technology.
Research Fields
1.Omics big data analysis and integration
2. Bioinformatics database
3.AI Agent for biological big data
Selected Publications
1. Zhang S, Chen X, Jin E, Wang A, Chen T, Zhang X, Zhu J, Dong L, Sun Y, Yu C, Zhou Y, Fan Z, Chen H, Zhai S, Sun Y, Chen Q, Xiao J, Song S, Zhang Z, Bao Y, Wang Y, Zhao W. The GSA Family in 2025: A Broadened Sharing Platform for Multi-omics and Multimodal Data. Genomics Proteomics Bioinformatics. 2025 Sep 22;23(4):qzaf072. doi: 10.1093/gpbjnl/qzaf072.
2. Wang Y, Lin Y, Wu S, Sun J, Meng Y, Jin E, Kong D, Duan G, Bei S, Fan Z, Wu G, Hao L, Song S, Tang B, Zhao W. BioKA: a curated and integrated biomarker knowledgebase for animals. Nucleic Acids Res. 2023 Oct 16:gkad873. doi: 10.1093/nar/gkad873.
3. Kang H, Huang T, Duan G, Meng Y, Chen X, He S, Xia Z, Zhou X, Chao J, Tang B, Wang Z, Zhu J, Du Z, Sun Y, Zhang S, Xiao J, Tian W, Wang W, Zhao W. TCOD: an integrated resource for tropical crops. Nucleic Acids Res. 2023 Oct 16:gkad870. doi: 10.1093/nar/gkad870.
4. Jin E, Zhao D, Wu G, Zhu J, Wang Z, Wei Z, Zhang S, Wang A, Tang B, Chen X, Sun Y, Zhang Z, Zhao W, Meng Y. OBIA: An Open Biomedical Imaging Archive. Genomics Proteomics Bioinformatics. 2023 Oct 6:S1672-0229(23)00108-0. doi: 10.1016/j.gpb.2023.09.003.
5. Sun Y, Zheng X, Wang G, Wang Y, Chen X, Sun J, Xiong Z, Zhang S, Wang T, Fan Z, Bu C, Bao Y, Zhao W. MACdb: A Curated Knowledgebase for Metabolic Associations across Human Cancers. Mol Cancer Res. 2023 Jul 5;21(7):691-697. doi: 10.1158/1541-7786.MCR-22-0909.
6. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. Nucleic Acids Res 2023, 51(D1):D18-D28.
7. Duan G, Wu G, Chen X, Tian D, Li Z, Sun Y, Du Z, Hao L, Song S, Gao Y, Xiao J, Zhang Z, Bao Y, Tang B, Zhao W*. HGD: an integrated homologous gene database across multiple species. Nucleic Acids Res. 2022 Nov 1:gkac970. doi: 10.1093/nar/gkac970.
8. Yu D, Zhu J, Yang J, Pan YH, Mu H, Cao R, Tang B, Duan G, Hao ZQ, Dai L, Zhao GP, Zhang YP, Zhao W*, Zhang G*, Li H*. Global cold-chain related SARS-CoV-2 transmission identified by pandemic-scale phylogenomics. Zool Res. 2022 Sep 18;43(5):871-874. doi: 10.24272/j.issn.2095-8137.2022.238.
9. Yu D, Yang X, Tang B, Pan YH, Yang J, Duan G, Zhu J, Hao ZQ, Mu H, Dai L, Hu W, Zhang M, Cui Y, Jin T, Li CP, Ma L; Language translation team, Su X, Zhang G, Zhao W*, Li H*. Coronavirus GenBrowser for monitoring the transmission and evolution of SARS-CoV-2. Brief Bioinform. 2022 Jan 19:bbab583. doi: 10.1093/bib/bbab583.
10. Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, Dong L, Zhang Z, Yu C, Sun Y, Chi L, Chen H, Zhai S, Sun Y, Lan L, Zhang X, Xiao J, Bao Y, Wang Y, Zhang Z, Zhao W. The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types. Genomics Proteomics Bioinformatics. 2021 Aug 13:S1672-0229(21)00163-7. doi: 10.1016/j.gpb.2021.08.001.
11. Wang ZH, Zhu QH, Li X, Zhu JW, Tian DM, Zhang SS, Kang HL, Li CP, Dong LL, Zhao WM*, Li MH*. iSheep: an Integrated Resource for Sheep Genome, Variant and Phenotype. Front Genet. 2021 Aug 17;12:714852. doi: 10.3389/fgene.2021.714852.
12. Wang K, Wang J, Zhu C, Yang L, Ren Y, Ruan J, Fan G, Hu J, Xu W, Bi X, Zhu Y, Song Y, Chen H, Ma T, Zhao R, Jiang H, Zhang B, Feng C, Yuan Y, Gan X, Li Y, Zeng H, Liu Q, Zhang Y, Shao F, Hao S, Zhang H, Xu X, Liu X, Wang D, Zhu M, Zhang G*, Zhao W*, Qiu Q*, He S*, Wang W*. African lungfish genome sheds light on the vertebrate water-to-land transition. Cell. 2021 Mar 4;184(5):1362-1376.e18. doi: 10.1016/j.cell.2021.01.047. PMID: 33545087.
13. Zhao WM*, Song SH*, Chen ML*, Zou D*, Ma LN*, Ma YK, Li RJ, Hao LL, Li CP, Tian DM, Tang BX, Wang YQ, Zhu JW, Chen HX, Zhang Z, Xue YB, Bao YM: The 2019 novel coronavirus resource. Yi Chuan 2020, 42(2):212-221. [PMID=32102777]
14. Tang B, Zhou Q, Dong L, Li W, Zhang X, Lan L, Zhai S, Xiao J, Zhang Z, Bao Y, Zhang Y, Wang G*, Zhao W*, iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Res. 2019, 47: D793-D800.
15. Zhang Z*, Zhao W*, Xiao J*, et al. The BIG Data Center: from deposition to integration to translation. Nucleic Acids Research. 2017, 45, D18-D24.
16. Wang Y, Song F, Zhu J, Zhang S, Yang Y, Chen T, Tang B, Dong L, Ding N, Zhang Q, Bai Z, Dong X, Chen H, Sun M, Zhai S, Sun Y, Yu L, Lan L, Xiao J, Fang X, Lei H, Zhang Z, Zhao W. GSA: Genome Sequence Archive. Genomics, Proteomics & Bioinformatics. 2017, 15:14-18.
Group Members
TANG Bixia, Associate professor
WANG Yanqing, Associate professor
CHEN Tingting, Associate professor
ZHU Junwei, Associate professor
ZHANG Sisi, Associate professor
ZHANG Xiaolong, Associate professor
WANG Anke, Assistant professor
DONG Lili, Engineer
YU Caixia, Engineer
FAN Zhuojing, Engineer
CHEN Xueping, Engineer
DUAN Qi, Engineer
REN Yifan, Postdoc
Contact: Zhaowm@cncb.ac.cn
