Introduction
Dr. LI Rujiao’s research group is strategically oriented to address the critical national needs for science and technology security and biological data security in the fields of life sciences and bioinformatics. The group has long been engaged in the construction of biological big data resource systems, the integration and secure governance of multi-omics data, and the independent development of key databases and core platforms.The databases led by the team, including MethBank, scMethBank, and the EWAS Open Platform, have formed a comprehensive platform covering epigenetic data–information–knowledge–tools across multiple species and hierarchical levels. Notably, in August 2025, the team’s “High-Quality DNA Methylation Dataset for Complex Human Traits” was selected as one of the first exemplary high-quality datasets by the National Data Administration.In recent years, the team has also actively applied artificial intelligence technologies to life science data mining and analysis, undertaking multiple projects.
Group leader：LI Rujiao
Biography
2023.06—Present, Professor Senior Engineer, Beijing Institute of Genomics, CAS（China National Center for Bioinformation）
2009.11—2023.05 Senior Engineer, Beijing Institute of Genomics, CAS（China National Center for Bioinformation）
2008.04—2009.10 Assistant Researcher, Beijing Institute of Genomics, CAS（China National Center for Bioinformation）
About Group Leader
Dr. LI Rujiao is a professor at Beijing Institute of Genomics, Chinese Academy of Sciences (CAS). Dr. LI received Ph.D. from Jilin University in 2005 and joined Beijing Institute of Genomics, CAS in 2008. His research interests are genomics and epigenomics. She mainly focuses on omics big data integration, analysis and mining, as well as development of biology databases and integration algorithms. She has published more than 40 papers in scientific journals, such as Nucleic Acids Research.
Research Fields
1. Integration and Mining of Biological Big Data
2. Development of algorithms for epigenomics data analysis
3. Design and development of life science database
4. Fine-tuning and development of AI models for identifying disease states based on multi-omics data
Selected Publications
1. Yang F#, Xiong Z#, Zong W#, Kong D#, Tang B, Chen X, Wei Y, Yu X, Zhang Y, Zou D, Zhang Z*, Bao Y*, Li R*, EWAS Open Platform 2026: a deeply integrated resource for epigenome-wide association studies, Nucleic Acids Res, 2026.
2. Li R# as co-first author in CNCB-NGDC and Partners (2026),Database resources of the National Genomics Data Center, China National Center for Bioinformation in 2026, Nucleic Acids Res, 2026.
3. Li R# as co-first author in CNCB-NGDC and Partners (2025),Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025, Nucleic Acids Res, 2025,53(D1): D30–D44.
4. Yang F#,Guo X#, Bao Y*, Li R*,The role of ribosomal DNA methylation in embryonic development, aging and diseases, Epigenetics & Chromatin, 2024,17:23.
5. Nie Z, ZhaoY#, Yu S#, Mai J, Gao H, Fan Z, Bao Y*, Li R*, Xiao J#, NucMap 2.0: An Updated Database of Genome-wide Nucleosome Positioning Maps Across Species, Journal of Molecular Biology，2024, 436(17):168655.
6. Yang S#, Zong W#, Shi L, Li R, Ma Z, Ma S, Si J, Wu Z, Zhai J, Ma Y, Fan Z, Chen S, Huang H, Zhang D, Bao Y*, Li R*, Xie J*, PPGR: a comprehensive perennial plant genomes and regulation database, Nucleic Acids Res, 2024, 52(D1):D1588-D1596.
7. Li R# as co-first author in CNCB-NGDC and Partners (2024), Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2024, Nucleic Acids Res, 2024, 52(D1):D18-D32.
8. Li R# as co-first author in CNCB-NGDC and Partners (2023), Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023, Nucleic Acids Res, 2023, 51(D1):D18-D28.
9. Wu S#, Huang Y#, Zhang M, Gong Z, Wang G, Zheng X, Zong W, Zhao W, Xing P , Li R* , Liu Z*, Bao Y* ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers, Nucleic Acids Res, 2023, 51(D1):D1196-D1204.
10. Zhang M#, Zong W#, Zou D#, Wang G#, Zhang X, Guo X, Ma Y, Zhao W, Yang F, Wu S, Xiong Z, Zhang Z*, Bao Y*, Li R*, MethBank 4.0: an updated database of DNA methylation across a variety of species, Nucleic Acids Res, 2023, 51(D1):D208-D216.
11. Wang G#, Xiong Z#, Yang F, Zheng X, Zong W, Li R*, Bao Y*, Identification of COVID-19-Associated DNA Methylation Variations by Integrating Methylation Array and scRNA-Seq Data at Cell-Type Resolution, Genes, 2022, 13, 1109.
12. Zong W#, Kang H#, Xiong Z, Ma Y, Jin T, Gong Z, Yi L, Zhang M, Wu S, Wang G, Bao Y*, Li R*, scMethBank: a database for single-cell whole genome DNA methylation maps, Nucleic Acids Res, 2022, 50(D1):D380-D386.
13. Xiong Z#, Yang F#, Li M#, Ma Y, Zhao W, Wang G, Li Z, Zheng X, Zou D, Zong W, Kang H, Jia Y, Li R*, Zhang Z*, Bao Y*, EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study, Nucleic Acids Res, 2022, 50(D1):D1004-D1009.
14. Li R# as co-first author in CNCB-NGDC and Partners (2022), Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022, Nucleic Acids Res, 50(D1):D27-D38.
15. Li R# as co-first author in CNCB-NGDC and Partners (2021), Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021, Nucleic Acids Res, 2021, 49(D1):D18-D28.
16. Li R# as co-first author in National Genomics Data Center Members and Partners (2020), Database Resources of the National Genomics Data Center in 2020, Nucleic Acids Res, 2020, 48(D1):D24-D33.
17. Zhao Y#, Wang J#, Liang F, Liu Y, Wang Q, Zhang H, Jiang M, Zhang Z, Zhao W, Bao Y, Zhang Z, Wu J, Asmann Y*, Li R*, Xiao J*, NucMap: a database of genome-wide nucleosome positioning map across species. Nucleic Acids Res，2019, 47(D1):D163-D169.
18. Li R#*, Liang F#, Li M#, Zou D#, Sun S, Zhao Y, Zhao W, Bao Y, Xiao J, Zhang Z*, MethBank 3.0: a database of DNA methylomes across a variety of species. Nucleic Acids Res，2018, 46(D1):D288-D295.
19. Li R# as co-first author in BIG Data Center Members, Database Resources of the BIG Data Center in 2018. Nucleic Acids Res, 2018, 46(D1): D14-D20.
20. Li R# as co-first author in BIG Data Center Members, The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res, 2017, 45(D1), D18-24.
21. Jin J#, Li R#, Jiang C, Zhang R, Ge X, Liang F, Sheng X, Dai W, Chen M, Wu J, Xiao J*, Su W*, Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells. BMC genomics, 2017,18(Suppl 1):933.
22. Peng B#, Pan Y#, Li R#, Wei J, Liang F, Wang L, Wang F, Qian W*, An Essential Regulatory System Originating from Polygenic Transcriptional Rewiring of PhoP-PhoQ of Xanthomonas campestris. Genetics, 2017.206(4):2207-2223.
23. Liang F, Hao L, Wang J, Shi S, Xiao J*, Li R*, BS-RNA: An efficient mapping and annotation tool for RNA bisulfite sequencing data. Computational biology and chemistry, 2016, 65:173-177.
Group Members
Staff:
Dr. YANG Fei, Senior Engineer, yangfei@cncb.ac.cn
Dr. ZHANG Mochen, Engineer, zhangmochen@cncb.ac.cn
Graduate Students：
ZONG Wenting, 2018.09-2024.12
ZHANG Yiran, 2022.09-2025.09
GUO Xutong, 2021.09-2024.06
LIU Yiyun, 2022.09
TIAN Lili, 2024.09
WEI Yaoke, 2024.09
LI Xinyi, 2025.09
YU Xiangyu, 2025.09
Contact: 010-84097638
