Introduction
The Operation and Maintenance Support Department is responsible for the operation and maintenance of the core infrastructure of the China National Center for Bioinformation, including computing, storage, backup, network and information security systems, as well as the data center environment. It is also in charge of the management, maintenance and utilization of shared instruments and equipment; provides supporting services for bio-big data storage and computing, information analysis and functional research; and is responsible for building the technical support capabilities of the center's digital infrastructure and cybersecurity.
Group leader
Zhang Bing
Biography
Work Experience:
2025–Present, Senior Engineer & Director of the Operation and Maintenance Support Department, China National Center for Bioinformation.
2019–2024 Associate Senior Engineer, Group Leader of Genomics Technology Innovation Center, Beijing Institute of Genomics, Chinese Academy of Sciences (China National Center for Bioinformation).
2009–2019 Associate Senior Engineer, Group Leader of Genomics Research Platform, Beijing Institute of Genomics, Chinese Academy of Sciences.
2006–2009 Assistant professor, Core Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences.
Education Background:
2001–2006 Doctor of Philosophy in Bioinformatics, Zhejiang University.
1997–2001 Bachelor of Science in Microbiology, Anhui University.
Introduction
Dr. Zhang Bing，Senior Engineer，Director of Operation and Maintenance Support Department, China National Center for Bioinformation. Dr. Zhang obtained his PhD in Bioinformatics from Zhejiang University in 2006. He was selected as a Key Technical Talent of the Chinese Academy of Sciences in 2017. His main research interests cover bioinformatics analysis technologies, high-performance computing (HPC), and network security technologies. As a project leader or core member, he has successively undertaken or participated in various projects, including the National Natural Science Foundation of China projects, the Major Special Projects of the Ministry of Science and Technology, the National Key R&D Program projects, as well as the Instrument Function Development and Technological Innovation Projects of the Chinese Academy of Sciences. He has published 26 research papers in SCI-indexed journals, including Genome Biology, National Science Review, Protein & Cell, and The Plant Journal.
Research Fields
1. Genomics & Bioinformatics
2. High-performance computing
3. Network security technologies
Selected Publications
1. Li, H., Wu, S., Li, J., Xiong, Z., Yang, K., Ye, W., Ren, J., Wang, Q., Xiong, M., Zheng, Z., Zhang, S., Han, Z., Yang, P., Jiang, B., Ping, J., Zuo, Y., Lu, X., Zhai, Q., Yan, H., Wang, S., Ma, S., Zhang, B., Ye, J., Qu, J., Yang, Y. G., Zhang, F., Liu, G. H., Bao, Y. and Zhang, W: HALL: a comprehensive database for human aging and longevity studies. Nucleic Acids Res 2024;52:D909-D18.
2. M. Liu, C. Yu, Z. Zhang, M. Song, X. Sun, J. Pialek, J. Jacob, J. Lu, L. Cong, H. Zhang, Y. Wang, G. Li, Z. Feng, Z. Du, M. Wang, X. Wan, D. Wang, Y. L. Wang, H. Li, Z. Wang, B. Zhang#, Z. Zhang#: Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice. Genome biology 2022, 23(1):203.(co-corresponding author)
3. Y. S. Chen*, S. Lu*, B. Zhang*, T. Du, W. J. Li, M. Lei, Y. Zhou, Y. Zhang, P. Liu, Y. Q. Sun, Y. L. Zhao, Y. Yang, X. Peng, Y. G. Yang: Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome. Protein & cell 2022, 13(5):379-385. （co-first author）
4. X. Luo*, Y. Zhou*, B. Zhang*, Y. Zhang*, X. Wang, T. Feng, Z. Li, K. Cui, Z. Wang, C. Luo, H. Li, Y. Deng, F. Lu, J. Han, Y. Miao, H. Mao, X. Yi, C. Ai, S. Wu, A. Li, Z. Wu, Z. Zhuo, D. Da Giang, B. Mitra, M. F. Vahidi, S. Mansoor, S. A. Al-Bayatti, E. M. Sari, N. A. Gorkhali, S. Prastowo, L. Shafique, G. Ye, Q. Qian, B. Chen, D. Shi, J. Ruan, Q. Liu: Understanding divergent domestication traits from the whole-genome sequencing of swamp- and river-buffalo populations. National science review 2020, 7(3):686-701. （co-first author）
5. Z. Du*, L. Ma*, H. Qu*, W. Chen*, B. Zhang*, X. Lu, W. Zhai, X. Sheng, Y. Sun, W. Li, M. Lei, Q. Qi, N. Yuan, S. Shi, J. Zeng, J. Wang, Y. Yang, Q. Liu, Y. Hong, L. Dong, Z. Zhang, D. Zou, Y. Wang, S. Song, F. Liu, X. Fang, H. Chen, X. Liu, J. Xiao, C. Zeng: Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome. Genomics, proteomics & bioinformatics 2019, 17(3):229-247. （co-first author）
6. G. Zhang, M. Sun, J. Wang, M. Lei, C. Li, D. Zhao, J. Huang, W. Li, S. Li, J. Li, J. Yang, Y. Luo, S. Hu, B. Zhang: PacBio full-length cDNA sequencing integrated with RNA-seq reads drastically improves the discovery of splicing transcripts in rice. The Plant journal 2019, 97(2):296-305.
7. J. Wang, S. Gao, Y. Mostovoy, Y. Kang, M. Zagoskin, Y. Sun, B. Zhang, L. K. White, A. Easton, T. B. Nutman, P. Y. Kwok, S. Hu, M. K. Nielsen, R. E. Davis: Comparative genome analysis of programmed DNA elimination in nematodes. Genome research 2017, 27(12):2001-2014.
8. X. Yang, Y. Yang, B. F. Sun, Y. S. Chen, J. W. Xu, W. Y. Lai, A. Li, X. Wang, D. P. Bhattarai, W. Xiao, H. Y. Sun, Q. Zhu, H. L. Ma, S. Adhikari, M. Sun, Y. J. Hao, B. Zhang, C. M. Huang, N. Huang, G. B. Jiang, Y. L. Zhao, H. L. Wang, Y. P. Sun, Y. G. Yang: 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell research 2017, 27(5):606-625.
9. C. Tang, M. Yang, Y. Fang, Y. Luo, S. Gao, X. Xiao, Z. An, B. Zhou, B. Zhang, X. Tan, H. Y. Yeang, Y. Qin, J. Yang, Q. Lin, H. Mei, P. Montoro, X. Long, J. Qi, Y. Hua, Z. He, M. Sun, W. Li, X. Zeng, H. Cheng, Y. Liu, J. Yang, W. Tian, N. Zhuang, R. Zeng, D. Li, P. He, Z. Li, Z. Zou, S. Li, C. Li, J. Wang, D. Wei, C. Q. Lai, W. Luo, J. Yu, S. Hu, H. Huang: The rubber tree genome reveals new insights into rubber production and species adaptation. Nature plants 2016, 2(6):16073.
10. S. Wang, S. Wang, Y. Luo, L. Xiao, X. Luo, S. Gao, Y. Dou, H. Zhang, A. Guo, Q. Meng, J. Hou, B. Zhang, S. Zhang, M. Yang, X. Meng, H. Mei, H. Li, Z. He, X. Zhu, X. Tan, X. Q. Zhu, J. Yu, J. Cai, G. Zhu, S. Hu, X. Cai: Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host. Nature communications 2016, 7:12845.
11. L. Zhu, J. Zhong, X. Jia, G. Liu, Y. Kang, M. Dong, X. Zhang, Q. Li, L. Yue, C. Li, J. Fu, J. Xiao, J. Yan, B. Zhang, M. Lei, S. Chen, L. Lv, B. Zhu, H. Huang, F. Chen: Precision methylome characterization of Mycobacterium tuberculosis complex (MTBC) using PacBio single-molecule real-time (SMRT) technology. Nucleic acids research 2016, 44(2):730-743.
12. Z. Xu, R. J. Peters, J. Weirather, H. Luo, B. Liao, X. Zhang, Y. Zhu, A. Ji, B. Zhang, S. Hu, K. F. Au, J. Song, S. Chen: Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis. The Plant journal 2015, 82(6):951-961.
13. G. Zhang, J. Wang, J. Yang, W. Li, Y. Deng, J. Li, J. Huang, S. Hu, B. Zhang: Comparison and evaluation of two exome capture kits and sequencing platforms for variant calling. BMC genomics 2015, 16:581.
14. H. An, F. P. Douillard, G. Wang, Z. Zhai, J. Yang, S. Song, J. Cui, F. Ren, Y. Luo, B. Zhang, Y. Hao: Integrated transcriptomic and proteomic analysis of the bile stress response in a centenarian-originated probiotic Bifidobacterium longum BBMN68. Molecular & cellular proteomics : MCP 2014, 13(10):2558-2572.
15. P. Zhou, G. Zhang, S. Chen, Z. Jiang#, Y. Tang, B. Henrissat, Q. Yan, S. Yang, C. F. Chen, B. Zhang#, Z. Du: Genome sequence and transcriptome analyses of the thermophilic zygomycete fungus Rhizomucor miehei. BMC genomics 2014, 15:294. (co-corresponding author)
16. C. Zheng*, M. Choquer*, B. Zhang*, H. Ge, S. Hu, H. Ma, S. Chen: LongSAGE gene-expression profiling of Botrytis cinerea germination suppressed by resveratrol, the major grapevine phytoalexin. Fungal biology 2011, 115(9):815-832.（co-first author）
17. Y. Tao, J. Ruan, S. H. Yeh, X. Lu, Y. Wang, W. Zhai, J. Cai, S. Ling, Q. Gong, Z. Chong, Z. Qu, Q. Li, J. Liu, J. Yang, C. Zheng, C. Zeng, H. Y. Wang, J. Zhang, S. H. Wang, L. Hao, L. Dong, W. Li, M. Sun, W. Zou, C. Yu, C. Li, G. Liu, L. Jiang, J. Xu, H. Huang, C. Li, S. Mi, B. Zhang, B. Chen, W. Zhao, S. Hu, S. M. Zhuang, Y. Shen, S. Shi, C. Brown, K. P. White, D. S. Chen, P. J. Chen, C. I. Wu: Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(29):12042-12047.
Awards and Honors
Selected as a Key Technical Talent of the Chinese Academy of Sciences in 2017
Contact
zhangbing#cncb.ac.cn, please replace # with @.
