About Us
Address from the Director
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The year 2017 was a crucial year for implementing the Pioneer Initiative of the Chinese Academy of Sciences (CAS) and the 13th Five-Year Plan (2016-2020) for Beijing Institute of Genomics (BIG). With the guidance of the Thought on Socialism with Chinese Characteristics for a New Era, following the leadership of CAS, upholding the duty and responsibility of national strategic power of science and technology, all members of BIG worked hard with a united and pioneering spirit, and made significant progress in all fields of endeavor.

 

In 2017, we have made remarkable progress in talent recruitment. Three PIs, Dr. BAO Yiming, HAN Dali, and LI Mingkun, joined the institute with fresh thoughts and power. Dr. YANG Yungui was selected into the National “Innovative Talent Promotion Plan”. Dr. ZHANG Zhang was evaluated as “Excellent” in the final assessment of the “100 Talents Program” of CAS. Dr. LIU Jiang was selected into the National “New Century Talents Project”, and was awarded as the “Young or Middle-aged Expert with Outstanding Contributions”. The Epigenetics Frontier Research Team, organized by BIG, was selected into the “LU Jiaxi International Team Project” of CAS. BIG keeps conducting third-party academic outcomes assessment of PIs to assist junior scientists with their career development.

 

Output of Major Results. LIU Jiang group has made breakthrough in unraveling the global reprogramming of 3D chromatin during early embryonic development. YANG Yungui group has revealed a new mechanism for the modification and regulation of RNA m6A (N6-methyladenosine), established high-throughput sequencing at the single-base resolution and bioinformatics analysis techniques for m6A and m5C (5-methylcytosine). The BIG Data Center has developed the Genome Variation Map, the largest database on genomic sequence variations in China, releasing a whole package of new functionalities and tools of bioinformatics resources. WANG Qianfei group has revealed the role of recurrently-mutated genes of acute myeloid leukemia in maintaining the normal hematopoietic stem cell functions, identified key genomic alterations in aggressive NK-cell leukemia, and played a major role in the initiation of a multi-center precision medicine study for the treatment of children with acute myeloid leukemia using a novel low dose chemotherapy regimen.

 

Key scientific research tasks. The total amount of project contracts has exceeded 110 million RMB, including “International Life Omics Data Sharing Program” and “Whole-genome Sequencing and Systematic Analysis of the Chinese Population” supported by the National Key Research and Development Program, and “Accurate Medical Big Data Management Platform and Application Demonstration” supported by the Key Engineering Projects of Promoting Big Data Development from National Development and Reform Commission, and “Big Data-driven Innovation Demonstration Platform for Bioinformatics” supported by the Information Special Project of CAS. At the same time, we also gained funds assistance from the International Union of Biological Sciences for the project of “Biodiversity and Health Big Data opening Plan” and played a demonstration role in the construction of " Belt and Road" International Life Group Data Sharing Alliance.

 

Development of infrastructure. The first Sino archive for raw sequencing data named Genome Sequence Archive has been successfully developed by Big Data Center of BIG, CAS, which is called a significant contribution to the domestic data deposition, archive and sharing in China, also appears as the forth current main data center besides the other 3 in the world. Based on the strategy of the “Construction of Beijing Huairou National Science Center”, BIG has started the compiling work on the draft paper named “Precision Medicine and Data Information Frontier Cross Platform” in mid-December. In addition, the scientific journal Genomics, Proteomics & Bioinformatics (GPB) sponsored by our institute and Genetics Society of China, was selected for coverage in Science Citation Index Expanded and Journal Citation Reports/Science Edition in August, and was named one of “The Highest International Impact Academic Journals of China” for five years in a row.

 

In the past year, we also made efforts to enhance ideological education and cultural innovation, in order to promote staff to take a pioneering role in their work. For example, we set the institute motto, with the meaning as “To disseminate virtue and to investigate the way of things, pursuing for excellence and extraordinariness”. The Trade Union of BIG was successfully qualified as the “Home of Workers” after evaluation. By holding PI Salon activities to encourage free scientific discussion, recommending outstanding examples around us to learn from each other, and establishing the Inheritor Culture Forum to share stories and thoughts of masters, we have been trying to promote the atmosphere of innovation and improve the ideological level of staff and students to make more contributions for the institute.

 

With the coming of the new year 2018, I would like to extend my sincere thanks and best wishes to leaders at all levels and our friends at home and abroad for their long-term care, support and help to the reform and development of our institute.

                                                                                                                                                                                                                                                Director: